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Product Details
PA5-51464
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZC3H12B. Recombinant protein control fragment (Product #RP-91996).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2649796
Product Specific Information
Immunogen sequence: GRALVMTRMD SISDSRLYES NPVRQRRPPL CREQHASWDP LPCTTDSYGY HSYPLSNSLM QPCYEPVMVR SVPEKMEQLW RNPWVGMCND SREHMIPEHQ YQTYKNLCN
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
ZC3H12B, also known as MCPIP2, is a member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. The function of ZC3H12B is not well understood. Unlike other members of the ZC3H12 family, ZC3H12B has a RasGEF domain at the C-terminal of the zinc finger motif, suggesting its potential involvement in Ras-mediated signal transduction. It is highly expressed in brain, thymus, and testis, but unlike ZC3H12A and ZC3H12C, not expressed in macrophages after treatment with lipopolysaccharide (LPS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MCP-induced protein 2; Probable ribonuclease ZC3H12B; RP3-475B7.1; Zinc finger CCCH domain-containing protein 12B
Gene Aliases: CXorf32; MCPIP2; ZC3H12B
UniProt ID: (Human) Q5HYM0
Entrez Gene ID: (Human) 340554
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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