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ZEB1/2 Polyclonal Antibody

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Product Details

BS-4187R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Flow Cytometry (Flow)

1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ZEB1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Delta EF1; delta-crystallin enhancer binding factor 1; HRIHFB2411; MEB1; Negative regulator of IL2; NIL-2-A zinc finger protein; posterior polymorphous corneal dystrophy 3; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; unnamed protein product; Zfhep; Zinc finger E-box-binding homeobox 1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1a; Zinc finger homeobox protein 1b; Zinc finger homeodomain enhancer-binding protein

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Gene Aliases: 3110032K11Rik; 9130203F04Rik; [delta]EF1; AREB6; BZP; D130016B08Rik; DELTAEF1; FECD6; HRIHFB2411; HSPC082; KIAA0569; MEB1; Nil2; NIL2A; PPCD3; SIP-1; SIP1; SMADIP1; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZEB2; ZFHEP; ZFHX1A; ZFHX1B; Zfx1a; ZFX1B; Zfx1ha; Zfxh1b

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UniProt ID: (Human) P37275, (Human) O60315, (Mouse) Q64318, (Rat) Q62947, (Mouse) Q9R0G7

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Entrez Gene ID: (Human) 6935, (Human) 9839, (Mouse) 21417, (Rat) 25705, (Mouse) 24136, (Rat) 311071

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding metal ion binding E-box binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding phosphatase regulator activity R-SMAD binding nucleic acid binding double-stranded DNA binding transcription factor binding sequence-specific DNA binding molecular_function C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter pattern specification process nervous system development central nervous system development cell proliferation regulation of mesenchymal cell proliferation negative regulation of keratinocyte proliferation regulation of transforming growth factor beta receptor signaling pathway cell differentiation negative regulation of epithelial cell differentiation regulation of T cell differentiation in thymus keratinocyte proliferation negative regulation of endothelial cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter animal organ development embryonic camera-type eye morphogenesis embryonic morphogenesis embryonic skeletal system morphogenesis semicircular canal morphogenesis epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of smooth muscle cell differentiation cartilage development cellular response to amino acid stimulus cochlea morphogenesis neural crest cell migration somitogenesis neural tube closure endothelial cell proliferation negative regulation of fibroblast migration corpus callosum morphogenesis hippocampus development cell proliferation in forebrain corticospinal tract morphogenesis positive regulation of Wnt signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway myofibroblast differentiation stress fiber assembly endothelial cell migration positive regulation of melanocyte differentiation positive regulation of melanin biosynthetic process developmental pigmentation astrocyte activation collateral sprouting positive regulation of axonogenesis mammillary axonal complex development pyroptosis fibroblast activation positive regulation of canonical Wnt signaling pathway response to oxygen-glucose deprivation melanocyte migration positive regulation of lens fiber cell differentiation regulation of melanosome organization positive regulation of myofibroblast contraction regulation of myofibroblast cell apoptotic process regulation of blood-brain barrier permeability transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter negative regulation of cell proliferation response to activity forebrain development response to nutrient levels cellular response to transforming growth factor beta stimulus positive regulation of JUN kinase activity biological_process
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