ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Delta EF1; delta-crystallin enhancer binding factor 1; MEB1; Negative regulator of IL2; NIL-2-A zinc finger protein; posterior polymorphous corneal dystrophy 3; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; Zfhep; Zinc finger E-box-binding homeobox 1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1a; Zinc finger homeobox protein 1b; Zinc finger homeodomain enhancer-binding protein
Gene Aliases: 3110032K11Rik; 9130203F04Rik; [delta]EF1; AREB6; BZP; D130016B08Rik; DELTAEF1; FECD6; HRIHFB2411; HSPC082; KIAA0569; MEB1; Nil2; NIL2A; PPCD3; SIP-1; SIP1; SMADIP1; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZEB2; ZFHEP; ZFHX1A; ZFHX1B; Zfx1a; ZFX1B; Zfx1ha; Zfxh1b