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Product Details
BS-4187R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ZEB1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Delta EF1; delta-crystallin enhancer binding factor 1; MEB1; Negative regulator of IL2; NIL-2-A zinc finger protein; posterior polymorphous corneal dystrophy 3; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; Zfhep; Zinc finger E-box-binding homeobox 1; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1a; Zinc finger homeobox protein 1b; Zinc finger homeodomain enhancer-binding protein
Gene Aliases: 3110032K11Rik; 9130203F04Rik; [delta]EF1; AREB6; BZP; D130016B08Rik; DELTAEF1; FECD6; HRIHFB2411; HSPC082; KIAA0569; MEB1; Nil2; NIL2A; PPCD3; SIP-1; SIP1; SMADIP1; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZEB2; ZFHEP; ZFHX1A; ZFHX1B; Zfx1a; ZFX1B; Zfx1ha; Zfxh1b
UniProt ID: (Human) P37275, (Human) O60315, (Mouse) Q64318, (Rat) Q62947, (Mouse) Q9R0G7
Entrez Gene ID: (Human) 6935, (Human) 9839, (Mouse) 21417, (Rat) 25705, (Mouse) 24136, (Rat) 311071
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
transcription factor binding
zinc ion binding
E-box binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
phosphatase regulator activity
metal ion binding
R-SMAD binding
nucleic acid binding
double-stranded DNA binding
sequence-specific DNA binding
molecular_function
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
immune response
pattern specification process
central nervous system development
cell proliferation
negative regulation of cell proliferation
regulation of mesenchymal cell proliferation
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell differentiation
regulation of T cell differentiation in thymus
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
embryonic skeletal system morphogenesis
semicircular canal morphogenesis
regulation of smooth muscle cell differentiation
cartilage development
cellular response to amino acid stimulus
cochlea morphogenesis
neural crest cell migration
somitogenesis
neural tube closure
transcription from RNA polymerase II promoter
nervous system development
corpus callosum morphogenesis
hippocampus development
cell proliferation in forebrain
corticospinal tract morphogenesis
positive regulation of Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of melanocyte differentiation
positive regulation of melanin biosynthetic process
developmental pigmentation
collateral sprouting
positive regulation of axonogenesis
mammillary axonal complex development
melanocyte migration
positive regulation of lens fiber cell differentiation
regulation of melanosome organization
regulation of transcription, DNA-templated
cell differentiation
animal organ development
embryonic morphogenesis
response to activity
forebrain development
response to nutrient levels
cellular response to transforming growth factor beta stimulus
biological_process
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