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Immunogen sequence: AKYAWSGYVI ECPNCGVVYR SRQYWFGNQD PVDTVVRTEI VHVWPGTDGF LKDNNNAAQR LLDGMNFMAQ SVSELSLGPT KAVTSWLTDQ IAPAYWRPNS QILSCNKCAT SFKDNDTKHH CRACGEGFCD SCSSKTRPVP ERGWGPAPVR VCDNCYEARN VQLAVTEAQV DDEGGTLIAR KVGEAVQNTL GAVVTAIDIP LGLVKDAARP AYWVPDHEIL HCHNCRKEFS IKLSKH
Positive Samples: 293T; Cellular Location: Endoplasmic reticulum, Golgi apparatus, Golgi stack
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.
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Protein Aliases: Double FYVE-containing protein 1; phosphoinositide-binding protein SR3; protein phosphatase 1, regulatory subunit 172; SR3; Tandem FYVE fingers-1; tandem FYVE fingers-1 protein; Zinc finger FYVE domain-containing protein 1; zinc finger protein, subfamily 2A, member 1; zinc finger, FYVE domain containing 1
Gene Aliases: DFCP1; KIAA1589; PP10436; PPP1R172; SR3; TAFF1; ZFYVE1; ZNFN2A1
UniProt ID: (Human) Q9HBF4
Entrez Gene ID: (Human) 53349
Molecular Function: membrane trafficking regulatory protein
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