Predicted to react with Mouse samples.
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
Protein Aliases: hSARA; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; MADH-interacting protein; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; protein phosphatase 1, regulatory subunit 173; Receptor activation anchor; Smad anchor for receptor activation; Zinc finger FYVE domain-containing protein 9; zinc finger, FYVE domain containing 9
Gene Aliases: E030027L17; MADHIP; NSP; PPP1R173; SARA; SMADIP; ZFYVE9
UniProt ID: (Human) O95405