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Invitrogen
ZHX2 Recombinant Rabbit Monoclonal Antibody (8N7O2)
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FIGURE: 1 / 1
ZHX2 Antibody (MA5-55598) in WB
Western Blot analysis of various lysates using ZHX2 Recombinant Monoclonal Antibody (Product # MA5-55598) at 1:1,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 45s.
Product Details
MA5-55598
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8N7O2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 260-500 of human ZHX2.
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Immunogen Sequence: VPLNTTKYNS ALDTNATMIN SFNKFPYPTQ AELSWLTAAS KHPEEHIRIW FATQRLKHGI SWSPEEVEEA RKKMFNGTIQ SVPPTITVLP AQLAPTKVTQ PILQTALPCQ ILGQTSLVLT QVTSGSTTVS CSPITLAVAG VTNHGQKRPL VTPQAAPEPK RPHIAQVPEP PPKVANPPLT PASDRKKTKE QIAHLKASFL QSQFPDDAEV YRLIEVTGLA RSEIKKWFSD HRYRCQRGIV H
Target Information
Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AFP regulator 1; alpha fetoprotein regulation 1, adult; Alpha-fetoprotein regulator 1; Regulator of AFP; transcription factor ZHX2; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
Gene Aliases: Afr-1; AFR1; KIAA0854; mKIAA0854; RAF; ZHX2
UniProt ID: (Human) Q9Y6X8, (Mouse) Q8C0C0
Entrez Gene ID: (Human) 22882, (Mouse) 387609
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
mRNA catabolic process
somatic stem cell population maintenance
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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