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Product Details
PA5-103289
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZIC1/2/3/4/5, corresponding to a region within the internal amino acids.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2852641
Target Information
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GENA 29; heterotaxy 1; kumba; Odd paired-related protein; odd-paired homolog; odd-paired related; Opa-related protein; Zic family member 1 (odd-paired homolog, Drosophila); Zic family member 2 (odd-paired homolog, Drosophila); Zic family member 3 (odd-paired homolog, Drosophila); Zic family member 4 (odd-paired homolog, Drosophila); Zic family member 5 (odd-paired homolog, Drosophila); zic protein member 1; zinc family member 4 protein HZIC4; zinc family member 5 protein; Zinc finger protein 201; Zinc finger protein 203; Zinc finger protein of the cerebellum 1; Zinc finger protein of the cerebellum 2; Zinc finger protein of the cerebellum 3; Zinc finger protein of the cerebellum 4; Zinc finger protein of the cerebellum 5; Zinc finger protein ZIC 1; Zinc finger protein ZIC 2; Zinc finger protein ZIC 3; Zinc finger protein ZIC 4; Zinc finger protein ZIC 5
Gene Aliases: 1700049L20Rik; Bn; CRS6; HPE5; HTX; HTX1; Ka; Ku; Opr; RGD1561261; VACTERLX; ZIC; ZIC1; ZIC2; ZIC3; ZIC4; ZIC5; ZNF201; ZNF203
UniProt ID: (Human) Q15915, (Human) O95409, (Human) O60481, (Human) Q8N9L1, (Human) Q96T25, (Mouse) P46684, (Mouse) Q62521, (Mouse) Q61467, (Mouse) Q7TQ40
Entrez Gene ID: (Human) 7545, (Human) 7546, (Human) 7547, (Human) 84107, (Human) 85416, (Rat) 64618, (Mouse) 22771, (Rat) 361096, (Mouse) 22772, (Rat) 367944, (Mouse) 22773, (Rat) 315882, (Mouse) 22774, (Rat) 361095, (Mouse) 65100
Molecular Function:
C2H2 zinc finger transcription factor
transcription from RNA polymerase II promoter
pattern specification process
brain development
adult walking behavior
regulation of smoothened signaling pathway
spinal cord development
cell differentiation
positive regulation of protein import into nucleus
inner ear morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
visual perception
negative regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
heart looping
determination of left/right symmetry
anterior/posterior pattern specification
lung development
somatic stem cell population maintenance
determination of pancreatic left/right asymmetry
determination of left/right asymmetry in nervous system
determination of digestive tract left/right asymmetry
determination of liver left/right asymmetry
nervous system development
central nervous system development
biological_process
skeletal system development
regulation of transcription, DNA-templated
multicellular organism development
neural tube closure
retinal ganglion cell axon guidance
cilium organization
developmental pigmentation
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
forebrain development
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
metal ion binding
DNA binding
chromatin DNA binding
protein binding
sequence-specific DNA binding
molecular_function
nucleic acid binding
Performance Guarantee
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