Immunogen sequence: VTSLEWETMT ENEEVTSKPS SSQRADSHKG TSKRLQGSVP QVLDFEEECE WQVLASQWGN ETDERADTVK KVS
ZNF197 product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. ZNF197 is located in a cluster of zinc finger genes at 3p21. Two alternatively spliced transcripts encoding different isoforms have been described.
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Protein Aliases: pVHL-associated KRAB domain-containing protein; VHL-associated KRAB-A domain-containing protein; zinc finger protein 166; Zinc finger protein 197; zinc finger protein 20; Zinc finger protein with KRAB and SCAN domains 9; ZnF20
Gene Aliases: D3S1363E; P18; VHLaK; ZKSCAN9; ZNF166; ZNF197; ZNF20; ZSCAN41
UniProt ID: (Human) O14709
Entrez Gene ID: (Human) 10168
Molecular Function: C2H2 zinc finger transcription factor