The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.
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Protein Aliases: Early hematopoietic zinc finger protein; Ecotropic viral integration site 3 protein; LYST-interacting protein 3; Zinc finger protein 521
Gene Aliases: B930086A16Rik; EHZF; Evi3; LIP3; Zfp521; ZNF521