ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.
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Protein Aliases: C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Zinc finger protein 598
Gene Aliases: BC023040; Ntrap; Zfp598; ZNF598
Molecular Function: ubiquitin-protein ligase