Recommended positive controls: 293T, A431, HepG2.
Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (90%), Xenopus laevis (90%), Chicken (89%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E. coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AARS; alanine tRNA ligase 1, cytoplasmic; Alanine--tRNA ligase, cytoplasmic; Alanyl-tRNA synthetase; alanyl-tRNA synthetase, cytoplasmic; AlaRS; Renal carcinoma antigen NY-REN-42
Gene Aliases: AARS; CMT2N; EIEE29
UniProt ID: (Human) P49588
Entrez Gene ID: (Human) 16