PA5-29516 targets alanyl-tRNA synthetase in WB applications and shows reactivity with Human and mouse samples.
The PA5-29516 immunogen is recombinant fragment corresponding to a region within amino acids 461 and 723 of Human alanyl-tRNA synthetase.
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The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
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Protein Aliases: AARS; alanine tRNA ligase 1; alanine tRNA ligase 1, cytoplasmic; alanine--tRNA ligase; Alanine--tRNA ligase, cytoplasmic; Alanyl-tRNA synthetase; alanyl-tRNA synthetase, cytoplasmic; AlaRS; CMT2N; cytoplasmic; Protein sticky; Renal carcinoma antigen NY-REN-42; Sti
Gene Aliases: AARS; AI316495; C76919; CMT2N; EIEE29; sti