|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to internal residues of the alpha-2c Adrenergic Receptor.|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||1:100 - 1:300|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA1-4518 detects alpha-2c AR in human, rat, and mouse samples.
PA1-4518 has been successfully used in Western blot and Immunohistochemistry procedures.
The PA1-4518 immunogen is a synthetic peptide corresponding to internal residues of the alpha-2c Adrenergic Receptor.
Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid repeated freeze-thaw cycles.
The alpha-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. There are 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha2C is required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Pre- and postsynaptic effects of norepinephrine on ¿-aminobutyric acid-mediated synaptic transmission in layer 2/3 of the rat auditory cortex.
PA1-4518 was used in immunohistochemistry to investigate the effect of norepinephrine on gamma-aminobutyric acid-mediated synaptic transmission
|Salgado H,Garcia-Oscos F,Martinolich L,Hall S,Restom R,Tseng KY,Atzori M||Synapse (New York, N.Y.) (66:20)||2012|