PA1-4518 detects alpha-2c AR in human, rat, and mouse samples.
PA1-4518 has been successfully used in Western blot and Immunohistochemistry procedures.
The PA1-4518 immunogen is a synthetic peptide corresponding to internal residues of the alpha-2c Adrenergic Receptor.
Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid repeated freeze-thaw cycles.
The alpha-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. There are 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha2C is required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2CAR; alpha2-AR-C4; subtype alpha2-C4
Gene Aliases: [a]2C; Adra-2c; ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; alpha2-C4; alpha2C; ALPHA2CAR