Invitrogen

alpha Adducin Polyclonal Antibody

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alpha Adducin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of alpha Adducin in paraffin-embedded Mouse Kidney tissue. Samples were incubated with polyclonal antibody (Product # PA5-118937) at a dilution of 20 µg/mL.

alpha Adducin Antibody in Western Blot (WB) — Western blot analysis of alpha Adducin in Lane 1: Wild-type K562 cell lysate; Lane 2: ADD1 knockout K562 cell lysate . Samples were incubated with polyclonal antibody (Product # PA5-118937) at a dilution of 1 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 0.2 µg/mL.

Product Details

PA5-118937

Applications	Tested Dilution	Publications
Western Blot (WB)	0.5-2 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	5-20 µg/mL	-
Immunocytochemistry (ICC/IF)	5-20 µg/mL	-

Product Specifications
Species Reactivity	Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant protein Alpha Adducin
Conjugate	Unconjugated
Form	Liquid
Concentration	500 µg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS with 50% glycerol
Contains	0.05% Proclin 300
Storage conditions	-20°C

Target Information

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADD2; ADDB; Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; Alpha-adducin; beta Adducin; Erythrocyte adducin subunit alpha

Gene Aliases: Add1; AI256389

UniProt ID: (Mouse) Q9QYC0

Entrez Gene ID: (Mouse) 11518

Molecular Function: non-motor actin binding protein