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Invitrogen
alpha Catenin Polyclonal Antibody
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FIGURE: 1 / 15
alpha Catenin Antibody (71-1200) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of A431 (Lane 1), A549 (Lane 2), CaCo2 (Lane 3), MCF7 (lane 4) and HT-29 (lane 5). The blots were probed with Anti-alpha Catenin Rabbit Polyclonal Antibody (Product # 71-1200, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). Two bands ~ 100 and 59 kDa corresponding to alpha Catenin was observed across cell lines tested. Known quantity of... View More
Product Details
71-1200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat,
Xenopus
Published species
Bovine,
Dog,
Hamster,
Human,
Mouse,
Rat,
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human alpha Catenin
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. It also regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Alpha catenin also functions in the control of the startle modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 102 kDa cadherin-associated protein; alpha E catenin; Alpha E-catenin; Alpha N-catenin; alpha(E)-catenin; alpha(N)-catenin; alpha-catenin; Alpha-catenin-related protein; alpha-E-catenin; alpha-N-catenin; alphaE-catenin; alphaN-catenin; cadherin associated protein; Cadherin-associated protein; cadherin-associated protein, related; cancer/testis antigen 114; CAP102; catenin; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin-associated protein), alpha 2; catenin alpha 1; catenin alpha 2; Catenin alpha-1; Catenin alpha-2; Catenin alpha1; Catenin alpha2; catenin, alpha 1; Catenin-alpha1; Catenin-alpha2; cerebellar deficient folia; epididymis secretory sperm binding protein; FLJ36832; FLJ52416; HGNC:2509; Neural alpha-catenin; NY-REN-13 antigen; Renal carcinoma antigen NY-REN-13; unnamed protein product
Gene Aliases: 2010010M04Rik; AA517462; AI481747; AI988031; CAP-R; CAP102; CAPR; Catna; Catna1; Catna2; CDCBM9; cdf; chp; CT114; CTNNA1; CTNNA2; CTNR; MDBS2; MDPT2
UniProt ID: (Human) P35221, (Chicken) P30997, (Human) P26232, (Mouse) P26231, (Mouse) Q61301
Entrez Gene ID: (Chicken) 416184, (Human) 1495, (Chicken) 396035, (Human) 1496, (Rat) 307505, (Mouse) 12385, (Mouse) 12386, (Rat) 297357
RNA binding
structural molecule activity
protein binding
beta-catenin binding
cytoskeletal protein binding
vinculin binding
identical protein binding
macromolecular complex binding
gamma-catenin binding
cadherin binding
actin filament binding
structural constituent of cytoskeleton
poly(A) RNA binding
non-motor actin binding protein
ovarian follicle development
apoptotic process
cell adhesion
establishment or maintenance of cell polarity
smoothened signaling pathway
integrin-mediated signaling pathway
neuroblast proliferation
negative regulation of neuroblast proliferation
protein localization
male gonad development
gap junction assembly
cell migration
axon regeneration
regulation of cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
apical junction assembly
response to estrogen
positive regulation of smoothened signaling pathway
cell motility
cellular response to indole-3-methanol
epithelial cell-cell adhesion
extrinsic apoptotic signaling pathway in absence of ligand
cell-cell adhesion
negative regulation of protein localization to nucleus
negative regulation of cell motility
negative regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
neural crest cell migration
axonogenesis
epithelial cell differentiation
dendrite morphogenesis
brain morphogenesis
regulation of synapse structural plasticity
trigeminal ganglion formation
cytoskeleton organization
regulation of neuron projection development
radial glia guided migration of Purkinje cell
cell differentiation
negative regulation of Arp2/3 complex-mediated actin nucleation
prepulse inhibition
modification of postsynaptic actin cytoskeleton
regulation of neuron migration
actin filament organization
aging
response to organic cyclic compound
cellular protein localization
protein heterooligomerization
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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