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Invitrogen
alpha-II Spectrin Polyclonal Antibody
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FIGURE: 1 / 5
alpha-II Spectrin Antibody (PA5-35383) in ICC/IF
Immunofluorescence analysis of alpha-II Spectrin was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with alpha-II Spectrin Polyclonal Antibody (Product # PA5-35383) at 1:250 dilution in 0.1% BSA and incubate... View More
Product Details
PA5-35383
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant construct containing the 7th, 8th, 9th repeats of human alpha II spectrin
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody contains enough material to conduct 10 mini-Western blots.
Target Information
SPTAN1 (spectrin alpha chain, non-erythrocytic 1) is a part of the spectrin family of filamentous cytoskeletal proteins. They function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (ALPHA)II-SPECTRIN; a--fodrin; alpha; alpha II spectrin; alpha-fodrin; Alpha-II spectrin; alpha-spectrin 2; alpha-spectrin 2, brain; brain; brain alpha-spectrin; FLJ44613; Fodrin alpha chain; inhibitory protein factor; noerythroid alpha-spectrin 2; Non erythrocytic spectrin alpha; non-erythrocytic 1 (alpha-fodrin); non-erythroid alpha chain; nonerythroid alpha-spectrin 2; Spectrin; Spectrin alpha; Spectrin alpha chain brain; spectrin alpha chain, brain; Spectrin alpha chain, non-erythrocytic 1; spectrin, non-erythroid alpha chain; Spectrin, non-erythroid alpha subunit
Gene Aliases: 2610027H02Rik; A2a; EIEE5; IPF; NEAS; Spna-2; Spna2; SPTA2; SPTAN1
UniProt ID: (Human) Q13813, (Rat) P16086
Entrez Gene ID: (Human) 6709, (Mouse) 20740, (Rat) 64159
actin binding
Ras guanyl-nucleotide exchange factor activity
structural constituent of cytoskeleton
calcium ion binding
protein binding
calmodulin binding
syntaxin binding
protein complex binding
protein N-terminus binding
cadherin binding involved in cell-cell adhesion
spectrin binding
metal ion binding
protein heterodimerization activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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