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Invitrogen
beta-2 Adrenergic Receptor Chimeric Recombinant Rabbit Monoclonal Antibody (R11/E1)
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FIGURE: 1 / 1
beta-2 Adrenergic Receptor Chimeric Antibody (MA5-48303) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of beta-2 Adrenergic Receptor in A431 cells using beta-2 Adrenergic Receptor Chimeric Monoclonal Antibody (Product # MA5-48303). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with beta-2 Adrenergic Receptor Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane stain... View More
Product Details
MA5-48303
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R11/E1
Immunogen
This antibody was raised by immunizing mice with beta-2 adrenergic receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: R11/E1 antibody recognizes human beta-2 adrenergic receptor. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; AR beta2; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286; putative; unnamed protein product
Gene Aliases: ADRB2; ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR
UniProt ID: (Human) P07550
Entrez Gene ID: (Human) 154
beta-amyloid binding
G-protein coupled receptor activity
adrenergic receptor activity
beta-adrenergic receptor activity
beta2-adrenergic receptor activity
protein binding
adenylate cyclase binding
potassium channel regulator activity
enzyme binding
identical protein binding
protein homodimerization activity
macromolecular complex binding
norepinephrine binding
regulation of systemic arterial blood pressure by norepinephrine-epinephrine
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
regulation of sodium ion transport
transcription from RNA polymerase II promoter
receptor-mediated endocytosis
smooth muscle contraction
regulation of smooth muscle contraction
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
endosome to lysosome transport
response to cold
positive regulation of bone mineralization
heat generation
negative regulation of multicellular organism growth
positive regulation of MAPK cascade
bone resorption
negative regulation of G-protein coupled receptor protein signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle contraction
brown fat cell differentiation
positive regulation of mini excitatory postsynaptic potential
adrenergic receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
regulation of blood vessel diameter
AMPA selective glutamate receptor signaling pathway
positive regulation of cold-induced thermogenesis
positive regulation of cAMP/PKA signal transduction
positive regulation of autophagosome maturation
positive regulation of lipophagy
cellular response to beta-amyloid
response to psychosocial stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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