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Invitrogen
beta-2 Adrenergic Receptor Chimeric Recombinant Rabbit Monoclonal Antibody (R11/E1)
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FIGURE: 1 / 1
beta-2 Adrenergic Receptor Chimeric Antibody (MA5-48303) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of beta-2 Adrenergic Receptor in A431 cells using beta-2 Adrenergic Receptor Chimeric Monoclonal Antibody (Product # MA5-48303). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with beta-2 Adrenergic Receptor Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane stain... View More
Product Details
MA5-48303
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R11/E1
Immunogen
This antibody was raised by immunizing mice with beta-2 adrenergic receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: R11/E1 antibody recognizes human beta-2 adrenergic receptor. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286
Gene Aliases: ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR
UniProt ID: (Human) P07550
Entrez Gene ID: (Human) 154
G-protein alpha-subunit binding
beta2-adrenergic receptor activity
protein binding
drug binding
adenylate cyclase binding
potassium channel regulator activity
B2 bradykinin receptor binding
protein complex binding
dopamine binding
ionotropic glutamate receptor binding
protein homodimerization activity
epinephrine binding
norepinephrine binding
G-protein coupled receptor
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
diaphragm contraction
positive regulation of the force of heart contraction by epinephrine
receptor-mediated endocytosis
cell surface receptor signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
female pregnancy
aging
positive regulation of cell proliferation
associative learning
endosome to lysosome transport
response to cold
positive regulation of sodium ion transport
negative regulation of angiogenesis
negative regulation of ossification
positive regulation of bone mineralization
positive regulation of protein ubiquitination
heat generation
response to progesterone
positive regulation of ATPase activity
response to testosterone
synaptic transmission, glutamatergic
negative regulation of urine volume
negative regulation of multicellular organism growth
wound healing
positive regulation of apoptotic process
positive regulation of potassium ion transport
positive regulation of MAPK cascade
response to estrogen
estrous cycle
bone resorption
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle contraction
positive regulation of skeletal muscle tissue growth
negative regulation of inflammatory response
brown fat cell differentiation
regulation of calcium ion transport
regulation of sensory perception of pain
excitatory postsynaptic potential
cellular response to hypoxia
response to dexamethasone
response to monoamine
adenylate cyclase-activating adrenergic receptor signaling pathway
negative regulation of platelet aggregation
liver regeneration
positive regulation of autophagosome maturation
positive regulation of lipophagy
positive regulation of mitophagy in response to mitochondrial depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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