Beta-arrestin 1 is a 418 amino acid containing signaling neurotransmitter that belongs to the arrestin family with an arrestin N terminal and an arrestin C terminal domain. A regulator of beta-adrenergic receptor function, Beta-arrestin 1 seems to bind to phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins. It is also reported to act as an activator of the lymphoid enhancer factor (LEF) transcription factor. Beta-arrestin 1 plays a crucial role in ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as an adaptor for the MDM2 E3 ligase. Purified beta-arrestin inhibits the signaling function of BARK-phosphorylated beta-adrenergic receptors by more than 75%, but not that of rhodopsin, and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most tissues.
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Protein Aliases: ARB1; ARR1; arrdc1; arrestin 2; Arrestin beta-1; arrestin, beta 1; Arrestin-2; Beta-arrestin-1; beta-arrestin1; Non-visual arrestin-2
Gene Aliases: 1200006I17Rik; ARB1; ARR1; ARRB1; AW208571; BARRES; BOS_14994; G430100A01Rik
Molecular Function: enzyme modulator