Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
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Protein Aliases: arrestin; arrestin 3; Arrestin beta-2; arrestin, beta 2; arrestin-3; beta arr2; beta-arrestin 2; beta-arrestin 2 long isoform; beta-arrestin 2 short isoform; Beta-arrestin-2; beta-arrestin2; DKFZp686L0365; HGNC:712; Non-visual arrestin-3; S-Arrestin
Gene Aliases: AI326910; ARB2; ARR2; ARRB2; AW122872; BARR2; BARRES
Molecular Function: scaffold/adaptor protein