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Invitrogen
c-Rel Polyclonal Antibody
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FIGURE: 1 / 3
c-Rel Antibody (PA5-47370) in WB
Western blot analysis of c-Rel in Raji human Burkitts lymphoma cell line, A20 mouse B cell lymphoma cell line, and CH‚1 mouse B cell lymphoma cell line. Samples were incubated in c-Rel polyclonal antibody (Product # PA5-47370) using a dilution of 0.5 µg/mL followed by a HRP-conjugated Anti-Goat IgG secondary antibody. A specific band was detected for c-Rel at approximately 69 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
PA5-47370
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse c-Rel Met1-Ile588
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA., RELB (604758), NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain, ' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (Belguise and Sonenshein, 2007).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCD541; C-Rel protein; C-Rel proto-oncogene protein; gemin 1; gemin-1; proto-oncogene c-Rel; SMA; SMA1; SMA2; SMA3; SMA4; SMN; SMN2; SMNT
Gene Aliases: c-Rel
Entrez Gene ID: (Mouse) 19696
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
cytokine production
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
inflammatory response
I-kappaB kinase/NF-kappaB signaling
negative regulation of gene expression
negative regulation of interferon-beta production
response to cytokine
NIK/NF-kappaB signaling
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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