Immunogen sequence: NWKLGDSPIQ KHKQLYPSCS FIQNLVSASL GSTSKNTSPM RNSFAHSLSP TLEHSSLFSG SYSSLSPNPL NSRAVEDISS SRTNPYSYAM STEEARFLTY HMWPLTFLSP SELARAGF
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.
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Protein Aliases: API1; apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; cIAP1; hIAP-2; IAP homolog B; IAP-2; inhibitor of apoptosis protein; Inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
Gene Aliases: API1; Api2; BIRC2; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; rIAP1; RNF48
UniProt ID: (Human) Q13490