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Invitrogen
eIF2b alpha Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 7
eIF2b alpha Antibody (PA5-28992) in ICC/IF
eIF2b alpha Polyclonal Antibody detects EIF2B1 protein at cytoplasm by immunofluorescent analysis. Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: EIF2B1 protein stained by eIF2b alpha Polyclonal Antibody (Product # PA5-28992) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
PA5-28992
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human EIF2B1 Recombinant protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546468
Product Specific Information
Recommended positive controls: 293T, A431, Jurkat, Raji.^M
^M
Predicted reactivity: Mouse (94%), Rat (92%), Bovine (95%).^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eIF-2B GDP-GTP exchange factor subunit alpha; eIF2B GDP-GTP exchange factor subunit alpha; eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa); eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; translation initiation factor eIF-2B subunit alpha; Translation initiation factor eIF2B subunit alpha
Gene Aliases: 26kDa; D5Ertd406e; EIF2B; EIF2B1; EIF2BA
UniProt ID: (Human) Q14232, (Mouse) Q99LC8
Entrez Gene ID: (Human) 1967, (Mouse) 209354
translational initiation
regulation of translational initiation
response to heat
response to glucose
oligodendrocyte development
L-methionine biosynthetic process from methylthioadenosine
response to peptide hormone
positive regulation of GTPase activity
cellular response to stimulus
translation
regulation of translation
negative regulation of translational initiation in response to stress
cellular metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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