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laminin Polyclonal Antibody
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FIGURE: 1 / 4
laminin Antibody (BS-0821R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat intestine tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-Laminin Polyclonal Antibody, Unconjugated (bs-0821R) at 1:500 overnight at 4°C, followed by a conjugated secondary a... View More
Product Details
BS-0821R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Laminin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dystrophia muscularis; Laminin A chain; laminin alpha 2 subunit; laminin B1; Laminin B1 chain; laminin B1 subunit 1; Laminin B2 chain; laminin B2 precursor; Laminin M chain; Laminin subunit alpha-1; Laminin subunit alpha-2; Laminin subunit beta-1; Laminin subunit gamma-1; laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, gamma 1 (formerly LAMB2); laminin-1; Laminin-1 subunit alpha; Laminin-1 subunit beta; Laminin-1 subunit gamma; Laminin-10 subunit beta; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-12 subunit alpha; Laminin-12 subunit beta; Laminin-2 subunit alpha; Laminin-2 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit alpha; Laminin-3 subunit gamma; Laminin-4 subunit alpha; Laminin-4 subunit gamma; Laminin-6 subunit beta; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit beta; Laminin-8 subunit gamma; Laminin-9 subunit gamma; Merosin heavy chain; mutant laminin subunit alpha 2; S-LAM alpha; S-LAM gamma; S-laminin subunit alpha; S-laminin subunit gamma; unnamed protein product
Gene Aliases: 5830440B04; AA408497; B2e; C77966; C80098; C81607; CLM; D130003D08Rik; dy; LAMA; Lama-1; LAMA1; LAMA2; Lamb-1; LAMB1; Lamb1-1; LAMB2; LAMC1; LAMM; LIS5; MDC1A; mer; merosin; mKIAA4087; PTBHS; S-LAM-alpha
morphogenesis of an epithelial sheet
cell adhesion
cell surface receptor signaling pathway
tissue development
regulation of cell adhesion
regulation of cell migration
neuron projection development
establishment of epithelial cell apical/basal polarity
positive regulation of cell adhesion
regulation of embryonic development
positive regulation of muscle cell differentiation
retina development in camera-type eye
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
retinal blood vessel morphogenesis
regulation of basement membrane organization
positive regulation of integrin-mediated signaling pathway
axon guidance
muscle organ development
Schwann cell differentiation
positive regulation of synaptic transmission, cholinergic
maintenance of blood-brain barrier
negative regulation of cell adhesion
embryo implantation
anatomical structure morphogenesis
cell migration
neuronal-glial interaction involved in cerebral cortex radial glia guided migration
positive regulation of cell migration
substrate adhesion-dependent cell spreading
endodermal cell differentiation
odontogenesis
positive regulation of epithelial cell proliferation
endoderm development
extracellular matrix disassembly
hemidesmosome assembly
protein-containing complex assembly
biological_process
myelination in peripheral nervous system
extracellular matrix organization
learning or memory
protein complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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