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Bethyl Laboratories
p73 Polyclonal Antibody
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Product Details
IHC-00197
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 1 and 62 of human tumor protein p73.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Small-eared galago, Crab-eating macaque and Green monkey
Target Information
P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; Tumor protein p73; unnamed protein product
Gene Aliases: CILD47; P73; TP73
UniProt ID: (Human) O15350
Entrez Gene ID: (Human) 7161
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
identical protein binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
DNA-binding transcription factor binding
promoter-specific chromatin binding
kidney development
release of cytochrome c from mitochondria
mismatch repair
regulation of transcription, DNA-templated
apoptotic process
inflammatory response
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to xenobiotic stimulus
post-embryonic development
regulation of gene expression
hippocampus development
forebrain development
cerebrospinal fluid secretion
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of MAPK cascade
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of cell size
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract morphogenesis
neuron development
positive regulation of oligodendrocyte differentiation
protein tetramerization
regulation of cell cycle
negative regulation of cardiac muscle cell proliferation
positive regulation of lung ciliated cell differentiation
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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