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pan Synuclein Antibody (PA5-78420) in ICC/IF
pan Synuclein Polyclonal Antibody detects pan Synuclein protein by immunofluorescent analysis. Sample: DIV14 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green: pan Synuclein protein stained by pan Synuclein Polyclonal Antibody (Product # PA5-78420) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody [GT1338] diluted at 1:500. Blue: F... View More
Product Details
PA5-78420
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of Rat pan Synuclein. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736318
Product Specific Information
Positive Control: mouse brain, rat brain
Predicted Reactivity: Human (93%), Xenopus laevis (84%), Pig (92%), Chicken (87%), Sheep (91%), Chimpanzee (93%), Bovine (91%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. The gamma-synuclein protein is found primarily in the peripheral nervous system and retina, but its expression in breast tumors makes it a candidate as a marker for tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-synuclein; Beta-synuclein; Gamma-synuclein; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Persyn; Phosphoneuroprotein 14; PNP 14; Sensory neuron synuclein; synuclein, gamma (breast cancer-specific protein 1)
Gene Aliases: AI838531; alphaSYN; betaSYN; C79089; NACP; Persyn; Snca; Sncb; Sncg; Syn
UniProt ID: (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754, (Rat) Q63544, (Mouse) Q9Z0F7
Entrez Gene ID: (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893, (Rat) 64347, (Mouse) 20618
magnesium ion binding
fatty acid binding
copper ion binding
calcium ion binding
protein binding
phospholipid binding
microtubule binding
ferrous iron binding
zinc ion binding
oxidoreductase activity
kinesin binding
enzyme binding
protein domain specific binding
Hsp70 protein binding
histone binding
identical protein binding
alpha-tubulin binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
phospholipase binding
dynein binding
protein N-terminus binding
tau protein binding
beta-tubulin binding
arachidonic acid binding
phosphoprotein binding
phospholipase D inhibitor activity
metal ion binding
membrane trafficking regulatory protein
microglial cell activation
positive regulation of receptor recycling
negative regulation of protein phosphorylation
positive regulation of neurotransmitter secretion
synaptic transmission, dopaminergic
fatty acid metabolic process
neutral lipid metabolic process
phospholipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial membrane organization
chemical synaptic transmission
aging
adult locomotory behavior
response to iron(II) ion
regulation of phospholipase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of glutamate secretion
regulation of dopamine secretion
negative regulation of microtubule polymerization
receptor internalization
protein destabilization
response to magnesium ion
negative regulation of transporter activity
response to lipopolysaccharide
negative regulation of monooxygenase activity
positive regulation of peptidyl-serine phosphorylation
response to interferon-gamma
cellular response to oxidative stress
negative regulation of histone acetylation
regulation of locomotion
response to cocaine
dopamine biosynthetic process
dopamine metabolic process
response to drug
mitochondrial ATP synthesis coupled electron transport
regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of endocytosis
negative regulation of exocytosis
negative regulation of dopamine metabolic process
regulation of neurotransmitter secretion
behavioral response to cocaine
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
synaptic vesicle endocytosis
synaptic vesicle transport
positive regulation of synaptic transmission
synapse organization
regulation of acyl-CoA biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
negative regulation of dopamine uptake involved in synaptic transmission
negative regulation of serotonin uptake
negative regulation of norepinephrine uptake
calcium ion homeostasis
oxidation-reduction process
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of inositol phosphate biosynthetic process
membrane organization
negative regulation of thrombin receptor signaling pathway
response to interleukin-1
cellular response to copper ion
positive regulation of protein serine/threonine kinase activity
regulation of neuron death
positive regulation of glutathione peroxidase activity
positive regulation of hydrogen peroxide catabolic process
regulation of reactive oxygen species metabolic process
aggressive behavior
peripheral nervous system development
protein secretion
cellular response to hydrostatic pressure
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