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Invitrogen
pro-Caspase 10 Polyclonal Antibody
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Product Details
PA5-149263
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human Pro Caspase-10, Met1-Pro228
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Pro-caspase 10 is the inactive precursor form of caspase 10, an important enzyme in the family of cysteine-aspartic proteases (caspases) involved in the regulation of apoptosis, or programmed cell death. Caspase 10 is primarily activated through the extrinsic apoptosis pathway, which is triggered by the binding of death ligands, such as Fas ligand (FasL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), to their respective death receptors on the cell surface. Upon activation, pro-caspase 10 is cleaved into its active form, which then initiates a cascade of proteolytic events leading to cell death. This process is crucial for maintaining cellular homeostasis, eliminating damaged or infected cells, and regulating immune responses. Dysregulation of caspase 10 activity can contribute to various pathological conditions, including cancer, autoimmune diseases, and neurodegenerative disorders. For instance, mutations or alterations in the expression of pro-caspase 10 can lead to impaired apoptosis, allowing cancer cells to evade cell death and proliferate uncontrollably. Understanding the regulation, activation, and function of pro-caspase 10 is essential for developing therapeutic strategies aimed at modulating apoptosis in disease contexts. Research into pro-caspase 10 provides valuable insights into the mechanisms of cell death and the potential for targeting apoptotic pathways in the treatment of cancer and other diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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