Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Human OX40L quantitates human OX40L in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human OX40L.
The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : CD134L, CD252, GP34, OX-40L, OX4OL, TNFSF4, TNLG2B, TXGP1
Gene ID : (Human) 7292
Gene symbol : TNFSF4
Protein Aliases : CD134 ligand, CD252, Glycoprotein Gp34, OX40 antigen ligand, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, tax-transcriptionally activated glycoprotein 1 (34kD), tumor necrosis factor (ligand) superfamily member 4, tumor necrosis factor ligand 2B, Tumor necrosis factor ligand superfamily member 4
UniProt ID (Human) P23510
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