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Invitrogen
Human ST2 (IL-33R) ELISA Kit
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Product Specifications
Analytical sensitivity
4.6 pg/mL
Assay range
4.7-300 pg/mL
Sample type/volume
Cell Lysate
10 µL
Plasma
10 µL
Serum
10 µL
Hands-on time
1 hr 20 min
Time-to-result
3 hr 10 min
Homogenous (no wash)
No
Interassay CV
3.5%
Intraassay CV
4.5%
Instrument
Absorbance Microplate Reader
Product size
96 Tests
Contents
Pre-coated 96 well plate
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
Shipping conditions
Wet ice
Storage
2-8°C
Protein name
ST2
Target sub-specificity
Soluble
Protein family
Cytokine Receptor
Species (tested)
Human
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
About This Kit
The Human ST2 (IL-33R) ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of human ST2 (IL-33R).
Target information
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene aliases : DER4, FIT-1, IL1RL1, IL33R, ST2, ST2L, ST2V, T1
Gene ID : (Human) 9173
Gene symbol : IL1RL1
Protein Aliases : DER4, Fit-1, IL-1 R4, IL1R4, IL-1R4, IL-1RL1, IL-33R, Ly84, ST2, ST2L, ST2V, suppression of tumorigenicity 2, T1, Interleukin1 receptor like 1, sIL 33R, soluble IL 33 Receptor, soluble IL 33R, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-like 1, interleukin 1 receptor-related protein, Interleukin-1 receptor-like 1, Protein ST2
UniProt ID (Human) Q01638
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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