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Invitrogen
Mouse CD223 (LAG-3) ELISA Kit
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Product Specifications
Analytical sensitivity
2.53 ng/mL
Assay range
2.53-800 ng/mL
Sample type/volume
Serum
100 µL
Supernatant
100 µL
Plasma
100 µL
Hands-on time
1 hr 20 min
Time-to-result
4 hr 45 min
Homogenous (no wash)
No
Interassay CV
12%
Intraassay CV
10%
Instrument
Absorbance Microplate Reader
Product size
96 Tests
Contents
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Sample Diluent
Wash Buffer Concentrate
Assay Buffer concentrate
Stop Solution
Substrate Solution
Adhesive Plate Covers
Shipping conditions
Wet ice
Storage
-20°C
Protein name
LAG-3 (CD223)
Species (tested)
Mouse
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
About This Kit
Mouse CD223 (LAG-3) ELISA Kit is an enzyme-linked immunosorbent assay for quantitative detection of mouse LAG-3 in cell culture supernatants, plasma, and serum samples.
Target information
LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene aliases : CD223, LAG-3, Lag3, Ly66
Gene ID : (Mouse) 16768
Gene symbol : Lag3
Protein Aliases : Activation-induced cytidine deaminase-linked autoimmunity protein, Aida, CD223, LAG-3, Lymphocyte activation gene 3 protein, sLAG 3, sLAG3, soluble LAG 3lymphocyte activating 3, soluble LAG3
UniProt ID (Mouse) Q61790
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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