Custom Chromatography Resin | Thermo Fisher Scientific

Addressing complex purification requirements

Increasing molecular complexity, closely related impurities, and heterogeneous feedstreams can quickly expose the limits of standard chromatography resins. Variants may co-elute, selectivity can plateau, and operating windows may narrow as developers adjust buffers, residence times, or load conditions with diminishing returns.

Thermo Fisher Scientific custom chromatography resin development services address these challenges when standard chromatography resins have been fully evaluated, and material properties become the primary limitation to process performance. By defining resin and ligand attributes around molecule- and process-specific constraints, customization focuses material design on purification needs rather than forcing process adaptation.

Custom chromatography resins aligned to your process

Standard affinity chromatography resins are often the starting point for downstream process (DSP) development, supporting a wide range of applications through established chemistries and operating modes. When process requirements fall outside the available formats due to molecule-specific behavior, feedstream complexity, or constrained operating windows, custom chromatography resins can be developed to meet defined process needs.

Options for custom chromatography resin development

Custom chromatography resin development includes services for CaptureSelect custom affinity resins and ligands, as well as custom POROS resins, helping address purification challenges across different stages of the downstream workflow. Resin properties are defined using structured, data-driven approaches to align selectivity, capacity, and operating behavior with molecule- and step-specific performance requirements.

Custom affinity resins and ligands

Enable highly selective capture when affinity options no longer resolve complexity or effectively discriminate between target and closely related variants. CaptureSelect custom affinity resin and ligand development defines selectivity and elution behavior around molecule-specific requirements.

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Custom POROS resins

Custom POROS resin development focuses on bead architecture and flow behavior when aggregate resolution, host cell protein (HCP) clearance, or pressure–flow constraints indicate that material properties are limiting process performance. This helps optimize resin selectivity.

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Supporting purification from development to commercial scale

Advance with confidence with our support as processes move from early development into scale-up and manufacturing readiness.

Prototype to large-scale commercial resin supply

With over 30 custom resins developed and used in scaled cGMP manufacturing processes, consistent performance and reliable supply are addressed from prototype to clinical scale and beyond.

Built for regulated development and manufacturing

Custom chromatography resins support use in regulated development and manufacturing environments. Our specialists have developed and manufactured chromatography resins for more than two decades.

Applications requiring tailored purification

Custom chromatography resin development services can be applied when molecule-specific behavior or process constraints limit the effectiveness of typical purification strategies. These applications often involve structural complexity or narrow operating windows that require resin properties to be defined around the molecule and downstream workflow.

Monoclonal, bi-, and multi-specific antibodies

Navigate purification challenges common to antibody-based modalities, where structural variants and closely related impurities can complicate both capture and polishing. Tailored chromatography resins help define selectivity and operating behavior that align with antibody-specific process demands.

Antibody-drug conjugates

Manage conjugation-driven heterogeneity that can complicate downstream purification of antibody-drug conjugates (ADCs). Custom chromatography resins support improved differentiation of species arising from variable drug loading or linker-related modifications when usual approaches reach their limits.

Recombinant proteins and enzymes

Accommodate purification needs for recombinant proteins and enzymes when sensitivity or impurity profiles restrict available operating conditions. Custom chromatography resin development enables alignment of separation behavior with functional and process-specific constraints.

Viral vectors and emerging modalities

Enable downstream purification for advanced modalities where established strategies may be limited or unavailable. Custom chromatography resin development supports workflows for viral vectors and other emerging molecule classes with distinct structural and process requirements.

Poster: Enabling custom solutions for downstream processing

Publication: Camelid VHH affinity ligands enable separation of closely related biopharmaceuticals

Webinar: Solving purification bottlenecks in biotherapeutics with custom resin solutions

Whitepaper: Custom chromatography solutions for complex biotherapeutics

Chromatography resources

Access additional chromatography resources for deeper technical support. These materials focus on purification fundamentals, resin behavior, and workflow considerations that can support decision-making during process development and optimization.

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