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SelectScreen Cell-Based Pathway Profiling Services

Advance drug discovery with comprehensive Cell Pathway Services that generate physiologically relevant data to characterize pathway activation, target engagement, and compound mechanism of action. Using validated cell-based assay technologies and experienced scientific expertise, we deliver actionable insights that support target validation, lead optimization, and confident decision-making throughout the discovery process.

 

Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen Cell-Based Pathway Profiling Service since their initiation in 2006. To date, our SelectScreen team has completed more than 500 cell-based pathway profiling projects, with an on-time delivery rate higher than 99%.

  • Access your data in real-time as soon as it’s available through our secure online portal
  • Broad panel of more than 250 cellular assays available
  • Robust compound management process: helps ensure sample quality and data consistency from project initiation through reporting
  • Complete lab information management system (LIMS): helps ensure project traceability and consistency

Project options

Customize your cell-based profiling project to get the right data for your research.

 

Standard service options include:

  • Targets: 5 Pathways (65 assays)
  • Mode: IC50 and/or EC50 determinations

Technology overview

Our SelectScreen Cell-Based Pathway Service utilizes CellSensor reporter gene assays.

 

Overview of available formats

 

CellSensor cell lines

 Technology overview Protocol and assay conditions

 

A stringent verification process helps ensure high-quality data, with each data point collected in duplicate.  Strict quality control protocols help ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration for each cell-based assay on every plate.

SelectScreen cell-based pathway profiling panel

If your target of interest is not on the list below, additional CellSensor Cell Lines may be profiled using our Custom Services.

Pathway

Cell line

Activator

Inhibitor

Antibody

CellSensor Cell Lines

Antioxidant response

ARE-bla HepG2

tBHQ

Ro-31-8220

N/A


B cell receptor

NFAT-bla RA-1

Goat anti-Human IgM

Syk Inhibitor II

N/A

cAMP/PKA

CRE-bla HEK 293T

Forskolin

H-89

N/A

cAMP/PKA

CRE-bla Jurkat

Forskolin

H-89

N/A

DNA damage/p53 Response

p53RE-bla HCT-116

Mitomycin

N/A

N/A

Glucocorticoid Receptor

MMTV-bla HeLa

Dexamethasone

RU-486

N/A

Heat Shock Response

HSE-bla HeLa

17-AAG

Quercetin

N/A

Hypoxia

HRE-bla ME-120

CoCl2

Chetomin

N/A

Interleukin 4/STAT6

STAT6-bla RA1

IL-4

JAK Inhibitor I

N/A

JAK/STAT

irf1-bla HEL

N/A

JAK Inhibitor I

N/A

JAK/STAT

ISRE-bla HEK 293T

IFN-alpha

JAK Inhibitor I

N/A

JAK/STAT

ISRE-bla Jurkat

IFN-alpha

JAK Inhibitor I

N/A

JAK/STAT

SIE-bla HEK 293T

IFN-gamma

JAK Inhibitor I

N/A

JAK/STAT

SIE-bla HEK 293T

IL-6

JAK Inhibitor I

N/A

JAK/STAT

SIE-bla ME-120

IL-6

JAK Inhibitor I

N/A

JAK/STAT

SIE-bla ME-120

IFN-gamma

JAK Inhibitor I

N/A

JAK2/STAT5

irf1-bla TF1

GM-CSF

JAK Inhibitor I

N/A

JAK2/STAT5

irf1-bla TF1

EPO

JAK Inhibitor I

N/A

MAPK

c-fos-bla HEK 293T

PMA

U0126

N/A

MAPK

c-fos-bla ME-120

EGF

PD153035

N/A

MAPK/EGFR/Ras/Raf

AP1-bla ME-120

EGF

PD153035

N/A

MAPK/MEK/B-raf

AP1-bla A375

N/A

Raf1 Kinase Inhibitor

N/A

NFkB

NFkB-bla Jurkat

TNF-alpha

Withaferin A

N/A

NFkB

NFkB-bla ME-120

TNF-alpha

Withaferin A

N/A

NFkB

NFkB-bla ME-120

IL-1 beta

Withaferin A

N/A

NFkB

NFkB-bla THP-1

TNF-alpha

Withaferin A

N/A

PKC/Ca2+

TrkA-NFAT-bla CHO-K1

NGF-2.5S

K252a

N/A

PKC/Ca2+

TrkB-NFAT-bla CHO-K1

BDNF

K252a

N/A

PKC/Ca2+

TrkC-NFAT-bla CHO-K1

Neurotrophin-3

K252a

N/A

PKC/Ca2+

NFAT-bla Jurkat

Thapsigargin

Ro-31-8220

N/A

T Cell Receptor

NFAT-bla Jurkat

anti-CD3:CD28

Ro-31-8220

N/A

TGF-beta

SBE-bla HEK 293T

TGF-beta

TGF-beta R1 Kinase Inhibitor

N/A

TNF-alpha/JNK

AP1-bla ME-120

TNF-alpha

JNK Inhibitor II

N/A

Toll-Like Receptor (TLR4)

NFkB-bla THP-1

LPS

Withaferin A

N/A

Wnt/Beta-Catenin

LEF/TCF-bla HCT-116

Wnt-3A

ICG-001

N/A

Wnt/Beta-Catenin (APC-/-)

LEF/TCF-bla SW 420

None

ICG-001

N/A

Personalized support

Personalized support is at the core of every SelectScreen project. From project initiation through data delivery, you'll work with a dedicated project manager who serves as your single point of contact, providing proactive communication, coordinating timelines and milestones, and ensuring proficient project execution.

 

Backed by experienced scientists and technical specialists, our team works as an extension of yours to deliver a responsive, collaborative experience and high-quality results tailored to your research goals.

For Research Use Only. Not for use in diagnostic procedures.