Cryo-EM Sample Preparation

Cryo-EM sample preparation workflow and techniques

Cryo-EM sample preparation directly impacts data quality and structural resolution. Well-prepared samples help you generate reliable, high-resolution results across a range of applications.

For single particle analysis, factors such as sample composition, purity, homogeneity, and stability influence cryo-EM specimen quality and downstream reconstruction outcomes. Maintaining biochemical activity is also critical for accurate structural interpretation.

For cryo-electron tomography (cryo-ET), careful sample handling preserves near-native conditions and supports accurate 3D visualization of cells and tissues.

We provide integrated solutions to support consistent, high-quality cryo-EM sample preparation across workflows.