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Proteintech
Caspase 6/p18/p11 Polyclonal Antibody
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Product Details
10198-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Caspase 6/p18/p11 Fusion Protein Ag0257 (59-222 aa encoded by BC000305)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LTLPERRGT CADRDNLTRR FSDLGFEVKC FNDLKAEELL LKIHEVSTVS HADADCFVCV FLSHGEGNHI YAYDAKIEIQ TLTGLFKGDK CHSLVGKPKI FIIQACRGNQ HDVPVIPLDV VDNQTEKLDT NITEVDAASV YTLPAGADFL MCYSVAEGYY SHRET (59-222 aa encoded by B C000305)
Target Information
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; mammalian Ced-3 homologue 2
Gene Aliases: CASP-6; CASP6; caspase-6; CSP-6; MCH2
UniProt ID: (Human) P55212, (Mouse) O08738
Entrez Gene ID: (Human) 839, (Mouse) 12368, (Rat) 83584
activation of innate immune response
proteolysis
apoptotic process
protein autoprocessing
epithelial cell differentiation
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
positive regulation of release of cytochrome c from mitochondria
hepatocyte apoptotic process
lens development in camera-type eye
acute inflammatory response to non-antigenic stimulus
response to heat
response to glucose
response to organic substance
response to metal ion
response to iron ion
response to organonitrogen compound
response to gamma radiation
response to estradiol
response to testosterone
response to cytokine
response to hydrogen peroxide
positive regulation of retinal cell programmed cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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