This product is manufactured in our Grand Island, US facility and is intended for sale in North America, Latin America, and the Asia/Pacific region—higher freight charges will apply to orders shipped elsewhere. An equivalent product, manufactured in Paisley, Scotland, is recommended for our customers in Europe, Africa, and the Middle East. Click to view.

CMRL Medium, no glutamine This product, and/or its packaging, incorporates one or more environmental/green features. Click on this icon to learn more.

Catalog number: 11530037

Gibco™  Related applications: Mammalian Cell Culture

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CMRL medium was originally developed by Connaught Medical Research Laboratories for the growth of Earle's "L"cells under serum-free conditions. CMRL medium is also especially useful for cloning monkey kidney cells and for growth of many other mammalian cell lines when supplemented with horse or calf serum.
This CMRL medium is manufactured as follows:
• Phenol Red• L-glutamine

The complete formulation is available.

Gibco® CMRL medium is a modified version of Medium 199. CMRL medium is particularly rich in nucleosides and vitamins

Product Intended Use
For in vitro diagnostic use. CAUTION: Not for human or animal therapeutic use. Uses other than the labeled intended use may be a violation of local law.

Dual-Site cGMP Manufacturing
Gibco® CMRL medium is manufactured at a cGMP compliant facility, located in Grand Island, New York. The facility is registered with the FDA as a medical device manufacturer and is certified to ISO 13485 standards. For supply chain continuity, we offer an identical Gibco® CMRL medium product made in our Scotland facility (21530-027). This facility is registered with the FDA as a medical device manufacturer and is certified to the ISO 13485 standard.

CMRL medium contains no proteins or growth factors. Therefore, CMRL medium requires supplementation, commonly with 10% Fetal Bovine Serum (FBS). CMRL medium uses a sodium bicarbonate buffer system (2.2 g/L) and therefore requires a 5-10% CO2 environment to maintain physiological pH.

“This reagent is classified as a medical device in several countries. If it is not regulated as a medical device in specific region, it should be used for laboratory use only.”
For Research Use Only. Not for use in diagnostic procedures.


Form: Liquid
Glucose: Low Glucose
Glutamine: No Glutamine
Product Size: 500 mL
Volume (Metric): 500 ml
Phenol Red Indicator: Phenol Red
Sodium Pyruvate Additive: No Sodium Pyruvate
Green Features: Fewer resources used, Less waste
Shipping Condition: Room Temperature

Contents & storage

Storage conditions: 2-8°C. Protect from light
Shipping conditions: Ambient
Shelf life: 12 months from date of manufacture

Media formulations


Manuals & protocols

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