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Invitrogen

FGFR1 Monoclonal Antibody (VBS-7)

1 Published Figure
6 References
View all (46) FGFR1 antibodies

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Additional Information:

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Product Details

13-3100

Applications
Tested Dilution
Publications

Western Blot (WB)

2 µg/mL
View 2 publications 2 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

-
View 2 publications 2 publications

Flow Cytometry (Flow)

-
View 1 publication 1 publication

ELISA (ELISA)

0.1-1.0 µg/mL
-

Immunoprecipitation (IP)

2-5 µg
-
Product Specifications

Species Reactivity

Bovine, Chicken, Guinea pig, Human, Mouse, Rat

Published species

Human, Mouse, Rabbit

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

VBS-7

Immunogen

Bovine FGF Receptor 1 (flg) purified from bovine Coronary Venular Endothelial Cells (CVEC).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

purified

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533011

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 2.7.10.1; basic fibroblast growth factor receptor 1; bFGF-R-1; CD331 antigen; cek1 protein; cek1 protein precursor; FGF Receptor; FGF receptor precursor; FGF receptor-1; FGF receptor-1 precursor; FGFR; fgfr 1; FGFR-1; FGFR1-IIIb; receptor tyrosine kinase; FGFR1/PLAG1 fusion; fibroblast growth factor receptor (FGFr) transmembrane form; fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome); fibroblast growth factor receptor 1-IIIc; fibroblast growth factor receptor FGFR-1 secreted form; fibroblast growth factor-receptor precursor; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; orf 5' of fibroblast growth factor receptor 1 FGFR-1; proto-oncogene c-Fgr; soluble form; FGF-R1; tyrosine kinase receptor CEK1; unnamed protein product

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Gene Aliases: bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CEK; Eask; ECCL; FGFBR; FGFR-1; FGFR-I; FLG; FLT-2; FLT2; Fr1; HBGFR; HH2; HRTFDS; Hspy; KAL2; MFR; N-SAM; OGD

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UniProt ID: (Human) P11362, (Chicken) P21804, (Mouse) P16092, (Rat) Q04589

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Entrez Gene ID: (Bovine) 281768, (Human) 2260, (Chicken) 396516, (Mouse) 14182, (Rat) 79114, (Guinea pig) 100731156

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding fibroblast growth factor binding identical protein binding protein homodimerization activity receptor-receptor interaction SH2 domain binding receptor binding macromolecular complex binding cell adhesion molecule binding transmembrane signal receptor
Process(es)
MAPK cascade skeletal system development neuron migration epithelial to mesenchymal transition protein phosphorylation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of phospholipase activity cell migration peptidyl-tyrosine phosphorylation chordate embryonic development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration cellular response to fibroblast growth factor stimulus regulation of cell differentiation positive regulation of cell differentiation positive regulation of neuron differentiation protein autophosphorylation phosphatidylinositol-mediated signaling generation of neurons skeletal system morphogenesis positive regulation of protein kinase B signaling positive regulation of vascular endothelial cell proliferation positive regulation of endothelial cell chemotaxis negative regulation of transcription from RNA polymerase II promoter angiogenesis ureteric bud development organ induction positive regulation of mesenchymal cell proliferation chondrocyte differentiation epicardial cell to mesenchymal cell transition transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development sensory perception of sound positive regulation of phospholipase C activity regulation of phosphate transport positive regulation of neuron projection development ventricular zone neuroblast division embryonic limb morphogenesis midbrain development positive regulation of kinase activity inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis positive regulation of transcription, DNA-templated paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vitamin D3 metabolic process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production positive regulation of mitotic cell cycle DNA replication positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of parathyroid hormone secretion regulation of extrinsic apoptotic signaling pathway in absence of ligand in utero embryonic development regulation of mitotic cell cycle brain development salivary gland morphogenesis gene expression regulation of gene expression regulation of cell cycle process negative regulation of gene expression positive regulation of cell communication positive regulation of fibroblast migration stem cell population maintenance orbitofrontal cortex development postnatal olfactory bulb interneuron migration forebrain generation of neurons central nervous system neuron development tangential migration from the subventricular zone to the olfactory bulb positive regulation of signaling lung development epithelial cell differentiation neuron projection development biomineral tissue development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development regulation of cell proliferation regulation of apoptotic process ear development negative regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter blood vessel morphogenesis mesenchymal cell differentiation regulation of phosphorus metabolic process calcium ion homeostasis vasculogenesis involved in coronary vascular morphogenesis diphosphate metabolic process cementum mineralization regulation of stem cell proliferation regulation of postsynaptic density assembly response to sodium phosphate positive regulation of hepatic stellate cell activation response to ischemia female pregnancy response to nutrient levels cellular response to lipopolysaccharide cellular response to growth factor stimulus cellular response to histamine cellular response to nerve growth factor stimulus
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