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Invitrogen
Transferrin Receptor Monoclonal Antibody (H68.4)
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FIGURE: 1 / 98
Transferrin Receptor Antibody (13-6890) in ICC/IF
Immunofluorescence analysis of Transferrin Receptor Monoclonal Antibody (H68.4) was performed using 70% confluent log phase MCF-7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Transferrin Receptor (H68.4) Mouse Monoclonal Antibody (Product # 13-6800... View More
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
.jpg?time=20220826?time=20220826 "Transferrin Receptor Antibody (13-6890) in ICC/IF")
.jpg?time=20220826?time=20220826 "Transferrin Receptor Antibody (13-6890) in WB, IHC")
Product Details
13-6890
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Hamster,
Human,
Mouse,
Rat
Published species
Bovine,
C. elegans,
Cat,
Chicken,
Dog,
Hamster,
Horse,
Human,
Insect,
Mammal,
Mouse,
Non-human primate,
Pig,
Rat,
Virus,
Yeast,
Zebrafish
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
H68.4
Immunogen
Recombinant human transferrin receptor.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
H68.4 is specific to residues 3-28 of the human transferrin receptor (TfR) tail.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD antigen CD71; mammary tumor virus receptor 1; tfR; tfR1; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 1; transferrin receptor 2; trfr; unnamed protein product
Gene Aliases: 2610028K12Rik; CD71; E430033M20Rik; I79_000642; IMD46; Mtvr1; p90; T9; TFR; TFR1; TFR2; TR; TRFR
UniProt ID: (Human) P02786, (Chicken) Q90997, (Rat) Q99376, (Mouse) Q62351, (Chinese hamster) Q07891
Entrez Gene ID: (Human) 7037, (Chicken) 396191, (Rat) 64678, (Mouse) 22042, (Chinese hamster) 100689395
regulation of cell growth
response to hypoxia
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
acute-phase response
cell surface receptor signaling pathway
response to nutrient
response to iron ion
response to manganese ion
positive regulation of gene expression
negative regulation of mitochondrial fusion
osteoclast differentiation
positive regulation of B cell proliferation
positive regulation of protein complex assembly
receptor internalization
response to retinoic acid
transferrin transport
intracellular signal transduction
positive regulation of T cell proliferation
regulation of cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of isotype switching
response to copper ion
multicellular organismal iron ion homeostasis
cellular response to xenobiotic stimulus
regulation of postsynaptic membrane neurotransmitter receptor levels
transport across blood-brain barrier
positive regulation of protein localization to nucleus
cellular response to leukemia inhibitory factor
iron ion transmembrane transport
cellular response to iron ion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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