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Invitrogen

Connexin 43 Monoclonal Antibody (CX-1B1), Alexa Fluor™ 488

1 Published Figure
1 Reference
View all (39) Connexin 43 antibodies

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Connexin 43 Monoclonal Antibody (CX-1B1), Alexa Fluor™ 488

Product Details

138388

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

-
View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

CX-1B1

Immunogen

Synthetic peptide corresponding to a cytoplasmic sequence located near the C-terminus of rat Connexin 43.
3D Epitope / Immunogen

Conjugate

Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488

Excitation/Emission Max

499/520 nm View spectra spectra

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

purified

Storage buffer

PBS, pH 7.4, with 4.5mg/mL BSA

Contains

0.1% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532181

Target Information

Connexin 43 (Cx43), encoded by the GJA1 gene, is a widely expressed gap junction protein that plays an important role in direct cell-to-cell communication. Six Cx43 proteins assemble to form a connexon, or hemichannel, which can pair with a connexon on a neighboring cell to create a gap junction channel. These channels allow ions, metabolites, and small signaling molecules to pass between adjacent cells, helping coordinate processes such as electrical conduction, tissue development, wound healing, and cellular homeostasis. Cx43 is especially abundant in tissues such as the heart, brain, bone, and skin, and changes in its expression, localization, or function have been associated with cardiovascular disease, neurological disorders, impaired tissue repair, and cancer. Because of its broad role in intercellular signaling and disease biology, Cx43 is an important target for studying gap junction function and developing potential therapeutic strategies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alpha 1 connexin; connexin 43; connexin k1; connexin-43; Cx-43; CXA1; DFNB38; gap junction 43 kDa heart protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); GJA1; Npm1; ODD; ODOD; SDTY3; Syndactyly type III; unnamed protein product; VEGF

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Gene Aliases: AVSD3; CMDR; Cnx43; connexin43; CX43; Cx43alpha1; Cxnk1; EKVP; EKVP3; Gja-1; GJAL; HLHS1; HSS; Npm1; ODDD; PPKCA

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UniProt ID: (Human) P17302, (Mouse) P23242, (Rat) P08050

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Entrez Gene ID: (Human) 2697, (Dog) 403418, (Mouse) 14609, (Rat) 24392

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Function(s)
receptor binding gap junction channel activity protein binding beta-catenin binding ion transmembrane transporter activity efflux transmembrane transporter activity tubulin binding transmembrane transporter activity glutathione transmembrane transporter activity alpha-tubulin binding beta-tubulin binding gap junction hemi-channel activity gap junction channel activity involved in cardiac conduction electrical coupling scaffold protein binding gap junction channel activity involved in cell communication by electrical coupling protein tyrosine kinase binding channel activity SH3 domain binding protein domain specific binding PDZ domain binding connexin binding disordered domain specific binding gap junction
Process(es)
establishment of mitotic spindle orientation cardiac conduction system development cell communication signal transduction cell-cell signaling spermatogenesis heart development protein localization male gonad development positive regulation of gene expression cell communication by electrical coupling glutamate secretion gap junction assembly negative regulation of cell growth negative regulation of gonadotropin secretion ion transmembrane transport glutathione transmembrane transport maintenance of blood-brain barrier T cell proliferation T cell activation xenobiotic transport positive regulation of I-kappaB kinase/NF-kappaB signaling cell-cell junction organization bone remodeling transmembrane transport bone development cellular response to pH atrial cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction microtubule-based transport positive regulation of cold-induced thermogenesis export across plasma membrane negative regulation of trophoblast cell migration regulation of blood circulation cellular response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation positive regulation of morphogenesis of an epithelium positive regulation of mesodermal cell differentiation positive regulation of stem cell proliferation regulation of apoptotic process osteoblast differentiation in utero embryonic development neuron migration negative regulation of endothelial cell proliferation heart looping epithelial cell maturation lens development in camera-type eye chronic inflammatory response positive regulation of glomerular filtration atrial ventricular junction remodeling epicardial cell to mesenchymal cell transition positive regulation of cytosolic calcium ion concentration adult heart development regulation of heart contraction negative regulation of cell proliferation response to pH vascular transport negative regulation of gene expression cell communication by chemical coupling regulation of cell communication by electrical coupling positive regulation of cell communication by chemical coupling ATP transport regulation of bone mineralization positive regulation of insulin secretion embryonic heart tube development maintenance of protein localization in endoplasmic reticulum vasodilation embryonic digit morphogenesis skeletal muscle tissue regeneration positive regulation of protein catabolic process positive regulation of meiotic nuclear division positive regulation of striated muscle tissue development positive regulation of vasoconstriction regulation of bone remodeling blood vessel morphogenesis neuron projection morphogenesis regulation of body fluid levels regulation of calcium ion transport negative regulation of cardiac muscle cell proliferation milk ejection regulation of ventricular cardiac muscle cell membrane repolarization regulation of blood vessel remodeling regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction establishment of epithelial cell polarity regulation of actin filament organization positive regulation of establishment of Sertoli cell barrier negative regulation of DNA biosynthetic process regulation of bicellular tight junction assembly positive regulation of behavioral fear response response to ischemia endothelium development response to wounding response to glucose response to estradiol response to lipopolysaccharide response to retinoic acid response to fluid shear stress cellular response to platelet-derived growth factor stimulus response to peptide hormone decidualization cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus positive regulation of smooth muscle cell chemotaxis epididymis development
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