Search

  • お問い合わせ一覧​
  • クイックオーダー

Invitrogen

ERK1 Monoclonal Antibody (ERK-6B11)

Advanced Verification
4 Published Figures
14 References
View all (51) ERK1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
ERK1 Monoclonal Antibody (ERK-6B11)

Product Details

13-8600

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 11 publications 11 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:250
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

Assay-dependent
View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat, Tag

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

ERK-6B11

Immunogen

Synthetic Peptide corresponding to a section of the C-terminus of rat ERK1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533041

Target Information

MAPK3 (ERK1) is a serine/threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ERK; ERK-1; Erk1; cancer susceptibility protein; ERK1b; ERK1c; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK 3; MAPK2; Microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MNK1; p44 MAP kinase; p44-ERK1; p44-MAPK; pp42/MAP kinase; unnamed protein product

View more View less

Gene Aliases: ERK-1; ERK1; ERT2; Esrk1; HS44KDAP; HUMKER1A; MAPK1; MAPK3; MNK1; Mtap2k; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3

View more View less

UniProt ID: (Human) P27361, (Rat) P21708, (Mouse) Q63844

View more View less

Entrez Gene ID: (Dog) 100855877, (Human) 5595, (Rat) 50689, (Mouse) 26417

View more View less

Function(s)
nucleotide binding phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding kinase activity transferase activity phosphatase binding identical protein binding protein serine kinase activity DNA-binding transcription factor binding scaffold protein binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
autophagosome assembly MAPK cascade negative regulation of T cell mediated immune response to tumor cell transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway insulin receptor signaling pathway organ morphogenesis regulation of gene expression negative regulation of autophagy positive regulation of autophagy positive regulation of macrophage chemotaxis neural crest cell development Schwann cell development phosphorylation sensory perception of pain regulation of ossification BMP signaling pathway regulation of cellular pH thyroid gland development positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway cellular response to nutrient levels positive regulation of telomere maintenance negative regulation of proteasomal ubiquitin-dependent protein catabolic process response to lipopolysaccharide regulation of stress-activated MAPK cascade cellular response to amino acid starvation intracellular signal transduction peptidyl-tyrosine autophosphorylation ERBB2-ERBB3 signaling pathway TORC1 signaling outer ear morphogenesis myelination glucose homeostasis signal transduction in response to DNA damage response to exogenous dsRNA positive regulation of transcription from RNA polymerase II promoter insulin-like growth factor receptor signaling pathway thymus development modulation of synaptic transmission protein stabilization negative regulation of T cell activation cartilage development stress-activated MAPK cascade regulation of cytoskeleton organization Bergmann glial cell differentiation face development lung morphogenesis trachea formation cardiac neural crest cell development involved in heart development interleukin-34-mediated signaling pathway ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway response to epidermal growth factor cellular response to mechanical stimulus cellular response to tumor necrosis factor caveolin-mediated endocytosis regulation of Golgi inheritance negative regulation of cholesterol efflux xenophagy positive regulation of macrophage proliferation positive regulation of neuroinflammatory response negative regulation of TORC1 signaling positive regulation of xenophagy regulation of early endosome to late endosome transport MAPK import into nucleus positive regulation of protein phosphorylation protein complex assembly DNA damage induced protein phosphorylation response to toxic substance peptidyl-serine phosphorylation arachidonic acid metabolic process positive regulation of histone phosphorylation positive regulation of histone acetylation positive regulation of translation positive regulation of transcription, DNA-templated regulation of sequence-specific DNA binding transcription factor activity negative regulation of apolipoprotein binding cell cycle signal transduction
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support