Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation.
AuthorsWang HY, Li W, Benedetti NJ, Lee DH,
JournalJ Biol Chem
PubMed ID12801934
'The Alzheimer''s disease pathogenic peptide, beta-amyloid42 (A beta 42), induces tau protein phosphorylation. Because hyperphosphorylated tau is a consistent component of neurofibrillary tangles, a pathological hallmark of Alzheimer''s disease, we investigated the signaling molecules involved in A beta 42-induced tau phosphorylation. We show that A beta 42 elicited rapid and ... More
Roscovitine targets, protein kinases and pyridoxal kinase.
AuthorsBach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, Baratte B, Koken M, Coburn SP, Tang L, Jiang T, Liang DC, Galons H, Dierick JF, Pinna LA, Meggio F, Totzke F, Schächtele C, Lerman AS, Carnero A, Wan Y, Gray N, Meijer L,
JournalJ Biol Chem
PubMed ID15975926
(R)-Roscovitine (CYC202) is often referred to as a
Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion.
AuthorsLim CS, Kim SH, Jung JG, Kim JK, Song WK,
JournalJ Biol Chem
PubMed ID14559906
SPIN90 is a widely expressed Nck-binding protein that contains one Src homology 3 (SH3) domain, three Pro-rich motifs, and a serine/threonine-rich region, and is known to participate in sarcomere assembly during cardiac myocyte differentiation. We used in vitro binding assays and yeast two-hybrid screening analysis to identify Nck, betaPIX, Wiscott-Aldrich ... More