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Invitrogen
Lamin A/C Monoclonal Antibody (3A6-4C11), eBioscience™
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FIGURE: 1 / 5
Lamin A/C Antibody (14-9847-82) in ICC/IF
Immunofluorescent analysis of Lamin A/C (green) in AF549 cells (40% confluency). The cells were fixed with 4% paraformaldehyde for 15 minutes at room temperature, permeabilized with 0.1% Triton X-100 for 10 minutes at 37C and blocked with 10% Normal Donkey Serum in PBS with 0.1% Triton X-100 for 1 hour at room temperature. Cells were stained with 0.06 µg/mL Lamin A/C mouse monoclonal antibody (Product # 14-... View More
Product Details
14-9847-82
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3A6-4C11
Immunogen
Recombinant fragment of human Lamin A
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: This 3A6-4C11 monoclonal antibody recognizes human and mouse Lamin A and Lamin C - two splice variants of the LMNA gene. The 3A6-4C11 antibody has been also reported to cross-react with rat Lamin A/C.
Applications Reported: This 3A6-4C11 antibody has been reported for use in western blotting and immunocytochemistry.
Applications Tested: This 3A6-4C11 antibody has been tested by western blotting of human and mouse cell line lysates. This may be used at 0.5 µg/mL.
Target Information
Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa lamin; epididymis secretory sperm binding protein; lamin A protein; Lamin A+C mutant; lamin a-c; lamin A/C; lamin A/C-like 1; Lamin AC; lamin C; lamin C protein; lamin-A/C; mandibuloacral dysplasia type A; mutant 453W; Mutant lamin A/C; Prelamin-A/C; progerin; progerin mutant; renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product
Gene Aliases: CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; MADA; PRO1
UniProt ID: (Human) P02545, (Mouse) P48678
Entrez Gene ID: (Human) 4000, (Mouse) 16905
nucleus organization
nuclear envelope organization
muscle organ development
establishment of cell polarity
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
protein localization to nucleus
sterol regulatory element binding protein import into nucleus
ventricular cardiac muscle cell development
negative regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway
protein import into nucleus
nuclear migration
protein localization
negative regulation of cell proliferation
positive regulation of gene expression
heterochromatin assembly
regulation of protein stability
regulation of telomere maintenance
nuclear pore localization
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
cellular senescence
protein localization to nuclear envelope
negative regulation of cardiac muscle hypertrophy in response to stress
DNA double-strand break attachment to nuclear envelope
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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