Recognition of galactan components of pectin by galectin-3.
AuthorsGunning AP, Bongaerts RJ, Morris VJ
JournalFASEB J
PubMed ID18832596
It has been reported that modified forms of pectin possess anticancer activity. To account for this bioactivity, it has been proposed that fragments of pectin molecules can act by binding to and inhibiting the various roles of the mammalian protein galectin 3 (Gal3) in cancer progression and metastasis. Despite this ... More
Mapping specific adhesive interactions on living human intestinal epithelial cells with atomic force microscopy.
AuthorsGunning AP, Chambers S, Pin C, Man AL, Morris VJ, Nicoletti C
JournalFASEB J
PubMed ID18263697
Specific molecular-receptor interactions with gut epithelium cells are important in understanding bioactivity of food components and drugs, binding of commensal microflora, attachment and initiation of defense mechanisms against pathogenic bacteria and for development of targeted delivery systems to the gut. However, methods for probing such interactions are lacking. Methodology has ... More