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Invitrogen
NMDAR1 Monoclonal Antibody (54.1)
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FIGURE: 1 / 46
NMDAR1 Antibody (32-0500) in ICC/IF
Immunofluorescent analysis of MAP2 (green) and NMDAR1 (red) on rat primary Hippocampal neurons (E18) (Product # A15587) cultured for 28 days in the B-27 Plus Neuronal Culture System (Product # A3653401). At day 28 the cells were fixed with 4% paraformaldehyde for 15 min, permeabilized with 0.1% triton x-100 for 30min, and blocked with 1% BSA for 30 min at room temperature. Cells were stained with anti-NMDAR1 antibody (Product # 32-0500) at a dilution of 1:100, and anti-MAP2 (Product # PA5-17646) at a dilution of 1:250, in 1% BSA staining b... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
32-0500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Fish,
Hamster,
Human,
Mouse,
Rat,
Tag
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
54.1
Immunogen
Fusion protein containing sequence from the intracellular loop between transmembrane regions III and IV of NMDAR1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody specifically recognizes the ~103 kDa NMDAR1 protein. Cross-reactivity with other NMDA receptor proteins has not been observed.
Target Information
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1
Gene Aliases: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174
UniProt ID: (Rat) P35439, (Mouse) P35438
Entrez Gene ID: (Rat) 24408, (Mouse) 14810
ionotropic glutamate receptor activity
NMDA glutamate receptor activity
receptor binding
extracellular-glutamate-gated ion channel activity
cation channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
glycine binding
glutamate binding
enzyme binding
voltage-gated cation channel activity
glutamate receptor binding
neurotransmitter binding
protein heterodimerization activity
protein dimerization activity
receptor activity
ion channel activity
transmembrane signal receptor
conditioned taste aversion
startle response
suckling behavior
response to amphetamine
cation transport
calcium ion transport
cellular calcium ion homeostasis
respiratory gaseous exchange
learning or memory
learning
memory
long-term memory
associative learning
adult locomotory behavior
olfactory learning
visual learning
regulation of cell communication
positive regulation of cell death
response to organic cyclic compound
response to amine
propylene metabolic process
sensory perception of pain
pons maturation
cerebral cortex development
ion transmembrane transport
regulation of ion transmembrane transport
social behavior
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
positive regulation of apoptotic process
response to morphine
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
rhythmic process
regulation of dendrite morphogenesis
regulation of axonogenesis
neuromuscular process
protein tetramerization
response to calcium ion
regulation of synapse assembly
calcium ion homeostasis
excitatory postsynaptic potential
prepulse inhibition
male mating behavior
response to fungicide
calcium ion transmembrane transport
cellular response to manganese ion
positive regulation of excitatory postsynaptic potential
transport
ion transport
chemical synaptic transmission
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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