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Invitrogen

Synuclein alpha/beta Monoclonal Antibody (Syn 202)

Advanced Verification
1 Published Figure
3 References
View all (6) Synuclein alpha/beta antibodies

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Additional Information:

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Product Details

32-8200

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
View 2 publications 2 publications

Immunohistochemistry (IHC)

Assay-dependent
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

Syn 202

Immunogen

Recombinant human alpha- and beta-synuclein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533095

Target Information

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 41 synuclein; I(2)-synuclein; I+/--synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; non-A4 component of amyloid precursor; phosphoneuroprotein 14; PNP 14; SNCA; SNCB; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); unnamed protein product

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Gene Aliases: alpha-Syn; alphaSYN; betaSYN; NACP; PARK1; PARK4; PD1

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UniProt ID: (Human) P37840, (Human) Q16143, (Mouse) O55042, (Rat) P37377, (Mouse) Q91ZZ3, (Rat) Q63754

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Entrez Gene ID: (Human) 6622, (Human) 6620, (Mouse) 20617, (Rat) 29219, (Mouse) 104069, (Rat) 113893

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Function(s)
SNARE binding magnesium ion binding transcription regulatory region sequence-specific DNA binding actin binding enzyme inhibitor activity protein kinase inhibitor activity cysteine-type endopeptidase inhibitor activity fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding enzyme activator activity ferrous iron binding zinc ion binding lipid binding tubulin binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding phospholipase binding tau protein binding beta-tubulin binding phosphoprotein binding phospholipase D inhibitor activity dynein complex binding protein sequestering activity transporter regulator activity cuprous ion binding phospholipase inhibitor activity transition metal ion binding arachidonic acid binding binding, bridging
Process(es)
chemical synaptic transmission synaptic vesicle endocytosis synapse organization dopamine metabolic process negative regulation of neuron apoptotic process microglial cell activation positive regulation of receptor recycling positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process glutathione metabolic process mitochondrial membrane organization adult locomotory behavior response to xenobiotic stimulus response to iron(II) ion negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion synaptic vesicle exocytosis synaptic vesicle priming negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion response to lipopolysaccharide response to interferon-gamma cellular response to oxidative stress SNARE complex assembly positive regulation of SNARE complex assembly regulation of locomotion dopamine biosynthetic process mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation negative regulation of apoptotic process positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis negative regulation of dopamine metabolic process regulation of neurotransmitter secretion behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle transport positive regulation of inflammatory response positive regulation of synaptic transmission regulation of acyl-CoA biosynthetic process protein oligomerization protein tetramerization positive regulation of release of sequestered calcium ion into cytosol negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway regulation of microtubule cytoskeleton organization response to interleukin-1 cellular response to copper ion positive regulation of hydrogen peroxide catabolic process positive regulation of protein localization to cell periphery negative regulation of chaperone-mediated autophagy regulation of presynapse assembly amyloid fibril formation regulation of reactive oxygen species metabolic process negative regulation of transcription from RNA polymerase II promoter response to cocaine positive regulation of apoptotic process cellular response to fibroblast growth factor stimulus dopamine uptake involved in synaptic transmission calcium ion homeostasis cellular response to epinephrine stimulus fibril organization negative regulation of mitochondrial electron transport, NADH to ubiquinone regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process response to desipramine
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