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Invitrogen
Phospho-STAT5 beta (Tyr694) Monoclonal Antibody (ST5P-4A9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
33-6000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Sheep,
Rat
Published species
Human,
Mouse,
Tag
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
ST5P-4A9
Immunogen
A synthetic tyrosine phosphorylated peptide encompassing the conserved C-terminal tyrosine phosphorylation site (Y694) of murine STAT5. This peptide is conserved in human, bovine, sheep, and rat STAT5 proteins
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mammary gland factor STAT5B; Signal transducer and activator of transcription 5a; STA5B; STAT; stat5b; STAT5B; transcription factor; transcription factor; transcription factor STAT5B; unnamed protein product
Gene Aliases: GHISID2; STAT5; STAT5B
UniProt ID: (Bovine) Q9TUM3, (Human) P51692, (Rat) P52632, (Mouse) P42232
Entrez Gene ID: (Sheep) 101122961, (Bovine) 282376, (Human) 6777, (Rat) 25126, (Mouse) 20851
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein dimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
glucocorticoid receptor binding
identical protein binding
protein homodimerization activity
double-stranded DNA binding
sequence-specific DNA binding
DNA-binding transcription factor binding
DNA-binding transcription factor
luteinization
natural killer cell differentiation
JAK-STAT cascade
female pregnancy
lactation
positive regulation of cell proliferation
regulation of steroid metabolic process
cytokine-mediated signaling pathway
lipid storage
regulation of cell adhesion
regulation of epithelial cell differentiation
positive regulation of interleukin-2 production
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
progesterone metabolic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of B cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of erythrocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
development of secondary female sexual characteristics
development of secondary male sexual characteristics
positive regulation of inflammatory response
JAK-STAT cascade involved in growth hormone signaling pathway
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
signal transduction
taurine metabolic process
response to estradiol
cellular response to hormone stimulus
erythropoietin-mediated signaling pathway
regulation of multicellular organism growth
regulation of cell proliferation
response to peptide hormone
regulation of hemopoiesis
response to hypoxia
liver development
transcription from RNA polymerase II promoter
acute-phase response
sex differentiation
positive regulation of gene expression
positive regulation of smooth muscle cell migration
response to lipopolysaccharide
positive regulation of natural killer cell proliferation
positive regulation of natural killer cell differentiation
T cell differentiation in thymus
response to ethanol
positive regulation of gamma-delta T cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of natural killer cell mediated cytotoxicity
Peyer's patch development
positive regulation of smooth muscle cell proliferation
gland development
response to interleukin-2
response to interleukin-4
response to interleukin-15
positive regulation of fibroblast growth factor production
mast cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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