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Invitrogen
p38 MAPK beta Monoclonal Antibody (P38-11A5)
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FIGURE: 1 / 18
p38 MAPK beta Antibody (33-8700) in ICC/IF
Immunofluorescent analysis of p38-beta 2 MAPK Antibody (P38-11A5) was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with p38-beta 2 MAPK Antibody (P38-11A5) (Product # 33-8700) at 1µg/mL in 1% BSA and incubated for 3... View More
Product Details
33-8700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rabbit
Host/Isotype
Mouse
/ IgG1/IgG2a
Class
Monoclonal
Type
Antibody
Clone
P38-11A5
Immunogen
Recombinant, full-length human p38 beta-2; the product of the p38-beta gene
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
33-8700 has been successfully used in immunofluorescence and western blot.
33-8700 specifically recognizes the beta isoform of p38, with slight reactivity to p38-gamma.
Target Information
MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP kinase 11; MAP kinase p38 beta; MAP kinase p38-2; MAPK 11; MAPK11; mitogen activated protein kinase 11; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; protein kinase, mitogen activated kinase, 11, p38beta; SAPK2b; splicing isoform of p38Beta MAP Kinase; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b; unnamed protein product
Gene Aliases: MAPK11; p38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
UniProt ID: (Human) Q15759, (Mouse) Q9WUI1
Entrez Gene ID: (Human) 5600, (Mouse) 19094
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
osteoblast differentiation
positive regulation of gene expression
stress-activated protein kinase signaling cascade
positive regulation of interleukin-12 production
intracellular signal transduction
p38MAPK cascade
positive regulation of erythrocyte differentiation
positive regulation of muscle cell differentiation
stress-activated MAPK cascade
protein maturation
cardiac muscle cell proliferation
regulation of cardiac muscle cell proliferation
negative regulation of cardiac muscle cell proliferation
bone development
pyroptosis
cellular response to interleukin-1
cellular response to UV-B
cellular senescence
cellular response to virus
NLRP1 inflammasome complex assembly
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
response to stress
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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