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Invitrogen
VEGF Receptor 2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
36-0900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the N-terminal region of the mouse vascular endothelial growth factor receptor-2 (VEGFR-2, FLK-1, KDR) protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD309 antigen; fetal liver kinase 1; Flk-1; kinase NYK; platelet-derived growth factor receptor-related tyrosine kinase; protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; unnamed protein product; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor; VEGF receptor-2
Gene Aliases: 6130401C07; Flk-1; Flk1; Krd-1; Ly73; orv; sVEGFR-2; VEGFR-2; VEGFR2
UniProt ID: (Mouse) P35918
Entrez Gene ID: (Mouse) 16542
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
coreceptor activity
growth factor binding
vascular endothelial growth factor binding
identical protein binding
cadherin binding
angiogenesis
ovarian follicle development
patterning of blood vessels
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lymph vessel development
positive regulation of mesenchymal cell proliferation
negative regulation of systemic arterial blood pressure
endocardium development
endothelium development
endochondral bone growth
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
regulation of cell shape
gonad development
male gonad development
response to xenobiotic stimulus
positive regulation of signal transduction
positive regulation of endothelial cell migration
negative regulation of gene expression
positive regulation of macroautophagy
cell migration
peptidyl-tyrosine phosphorylation
hemopoiesis
lung development
positive regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of TOR signaling
embryonic hemopoiesis
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
vascular endothelial growth factor signaling pathway
vasodilation
surfactant homeostasis
regulation of MAPK cascade
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
cell fate commitment
endothelial cell differentiation
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of long-term neuronal synaptic plasticity
lung alveolus development
cell maturation
blood vessel morphogenesis
post-embryonic camera-type eye morphogenesis
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
calcium ion homeostasis
epithelial tube morphogenesis
blood vessel endothelial cell differentiation
vascular wound healing
endothelial tube morphogenesis
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of mitochondrial fission
positive regulation of nitric oxide-cGMP mediated signal transduction
regulation of hematopoietic progenitor cell differentiation
regulation of bone development
cellular response to hydrogen sulfide
negative regulation of endothelial cell apoptotic process
positive regulation of endothelial cell chemotaxis
positive regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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