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Invitrogen
CD138 Polyclonal Antibody
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FIGURE: 1 / 18
CD138 Antibody (36-2900) in IHC (P)
Immunohistochemistry analysis of Syndecan-1/CD138 showing staining in the cytoplasm and membrane of paraffin-embedded human small intestinal tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
36-2900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from an internal region of the human Syndecan-1 protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with the human Syndecan-1 (CD38) protein. On western blots, a single band at ~90 kDa representing the glycosylated form of CD138; occasionally a band of ~31 kDa representing the un-glycosylated form of CD138 may be observed. Reactivity has been confirmed with human T47D, SW-480, and PC-3 cell lysates by western blotting and with formalin-fixed, paraffin-embedded (FFPE) human gastric cancer and breast cancer tissues, and mouse and rat stomach, small bowel, and skin tissues by immunohistochemistry. For best results in immunohistochemistry with formalin-fixed, paraffin-embedded (FFPE) tissues, heat induced epitope retrieval (HIER) with EDTA, pH 8.0, is required prior to staining.
Target Information
CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD antigen 138; CD138 antigen; cell surface heparan sulfate proteoglycan; heparan sulfate proteoglycan core protein; heparan sulfate proteoglycan fibroblast growth factor receptor; sCD138; soluble CD138; syndecan; syndecan proteoglycan 1; Syndecan1; synstatin; unnamed protein product
Gene Aliases: CD138; HSPG; SDC; Sstn; syn-1; Synd; SYND1; SYNDECA; Syndecan
UniProt ID: (Human) P18827, (Rat) P26260, (Mouse) P18828
Entrez Gene ID: (Human) 6382, (Rat) 25216, (Mouse) 20969
ureteric bud development
receptor-mediated endocytosis
cell adhesion
cell-cell signaling
response to toxic substance
response to hydrogen peroxide
myoblast development
response to glucocorticoid
response to cAMP
response to calcium ion
striated muscle cell development
Sertoli cell development
canonical Wnt signaling pathway
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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