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Invitrogen
Nogo-A Polyclonal Antibody
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FIGURE: 1 / 6
Nogo-A Antibody (36-6600) in ICC/IF
The Biochemical journal 2013 -
Figure 5 Up-regulation of Nogo-A and Apg-1 under hypoxic stress ( A ) Hippocampal neurons were cultured for 4 days in vitro and exposed to chemical ischaemia for 15 min, fixed after 8 h, and stained for Apg-1 and Nogo-A. Single-cell semi-quantitative immunocytochemistry was performed by defining a primary object area in the Nogo-A channel (red line). Pixel intensity was measured within this primary object a... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
36-6600
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Hamster,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the internal region of rat Nogo-A (Reticulon 4-A, Foocen, Glut4 Vesicle 20kDa Protein), which differs from the human sequence by only one amino acid.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: foocen; glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; neurite outgrowth inhibitor; NI-220/250; Rtn4-B2; vp20
Gene Aliases: NI-250; Nogo; Nogo-A; rat N; rat NogoA; Vp20
UniProt ID: (Rat) Q9JK11
Entrez Gene ID: (Rat) 83765
blastocyst formation
leukocyte migration involved in inflammatory response
endoplasmic reticulum organization
nervous system development
axonal fasciculation
brain development
positive regulation of epithelial cell migration
negative regulation of neuron projection development
response to activity
olfactory nerve development
cerebral cortex radial glia guided migration
central nervous system vasculogenesis
neuron differentiation
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of mammary gland epithelial cell proliferation
positive regulation of dopamine secretion
positive regulation of toll-like receptor 9 signaling pathway
positive regulation of Rac protein signal transduction
cell migration involved in vasculogenesis
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
positive regulation of angiogenesis
positive regulation of collateral sprouting of injured axon
oligodendrocyte differentiation
negative regulation of axonogenesis
modulation of synaptic transmission
protein stabilization
nuclear pore complex assembly
positive regulation of protein kinase B signaling
regulation of nervous system development
cardiac epithelial to mesenchymal transition
positive regulation of macrophage cytokine production
protein localization to lysosome
negative regulation of neuron projection regeneration
cellular response to hypoxia
endoplasmic reticulum tubular network organization
endoplasmic reticulum tubular network assembly
cellular sphingolipid homeostasis
cell adhesion involved in sprouting angiogenesis
regulation of postsynapse assembly
negative regulation of beta-amyloid formation
positive regulation of neutrophil migration
negative regulation of dendrite extension
positive regulation of macrophage migration
positive regulation of protein localization to endoplasmic reticulum
positive regulation of ERBB3 signaling pathway
positive regulation of artery morphogenesis
negative regulation of formation of growth cone in injured axon
endoplasmic reticulum tubular network membrane organization
regulation of branching morphogenesis of a nerve
positive regulation of hepatocyte proliferation
negative regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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