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Invitrogen
EphA4 Monoclonal Antibody (4C8H5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
37-1600
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4C8H5
Immunogen
A synthetic peptide derived from the C-terminus human EphA4 receptor protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is specific for the endogenous EphA4 receptor protein. No cross-reactivity with EphA5 or EphA7 has been detected. On western blots, this antibody identifies a band at ~110-120 kDa. Reactivity has been confirmed with EphA4-transfected 293T cells and mouse brain lysates by western blot and immunoprecipitation and on transfected 293 cells and mouse hippocampus by immunohistochemistry.
Target Information
EPHA4 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA4 encodes a protein that binds ephrin-A ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cek8; EK8; epa4; EPH-like kinase 8; Eph-related receptor protein tyrosine kinase; receptor protein-tyrosine kinase HEK8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase receptor MPK-3; tyrosine-protein kinase receptor SEK; tyrosine-protein kinase receptor SEK-1; tyrosine-protein kinase TYRO1; unnamed protein product
Gene Aliases: 2900005C20Rik; Cek8; EK8; HEK8; rb; SEK; Sek1; TYRO1
UniProt ID: (Chicken) Q07496, (Human) P54764, (Mouse) Q03137
Entrez Gene ID: (Chicken) 395559, (Human) 2043, (Mouse) 13838
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
ATP binding
PH domain binding
identical protein binding
DH domain binding
protein tyrosine kinase binding
beta-amyloid binding
protein tyrosine kinase activity
ephrin receptor activity
protein binding
kinase activity
ephrin receptor binding
transmembrane signal receptor
somitogenesis
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
axon guidance
adult walking behavior
motor neuron axon guidance
peptidyl-tyrosine phosphorylation
corticospinal tract morphogenesis
positive regulation of kinase activity
adherens junction organization
segmentation
regulation of GTPase activity
positive regulation of JUN kinase activity
protein autophosphorylation
ephrin receptor signaling pathway
negative regulation of axon regeneration
regulation of astrocyte differentiation
regulation of axonogenesis
protein stabilization
regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
nephric duct morphogenesis
cochlea development
fasciculation of sensory neuron axon
fasciculation of motor neuron axon
synapse pruning
negative regulation of long-term synaptic potentiation
positive regulation of beta-amyloid formation
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
cellular response to beta-amyloid
regulation of modification of synaptic structure
positive regulation of Rho guanyl-nucleotide exchange factor activity
negative regulation of cell adhesion
positive regulation of cell proliferation
glial cell migration
negative regulation of epithelial to mesenchymal transition
negative regulation of neuron projection development
negative regulation of translation
positive regulation of cell migration
negative regulation of cell migration
positive regulation of cell adhesion
positive regulation of JNK cascade
positive regulation of dendrite morphogenesis
negative regulation of ERK1 and ERK2 cascade
neuron projection guidance
neuron projection fasciculation
negative regulation of cellular response to hypoxia
positive regulation of intracellular signal transduction
positive regulation of amyloid precursor protein catabolic process
positive regulation of leukocyte adhesion to arterial endothelial cell
regulation of synapse pruning
deadenylation-dependent decapping of nuclear-transcribed mRNA
central nervous system projection neuron axonogenesis
negative regulation of neuron apoptotic process
negative regulation of translational initiation
animal organ development
regulation of developmental process
synapse organization
innervation
membraneless organelle assembly
cellular response to oxygen-containing compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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