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Invitrogen
PLK1 Monoclonal Antibody (35-206)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
37-7000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
35-206
Immunogen
Full-length human Plk1 (polo-like kinase 1)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PLK1 is a serine/threonine kinase that is thought to function in cell mitosis and regarded as a marker of cell proliferation. It has been found to play a critical role in carcinogenesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell cycle regulated protein kinase; PLK 1; PLK-1; polo (Drosophia)-like kinase; polo-like kinase; serine/threonine-protein kinase 13; STPK14; unnamed protein product
Gene Aliases: PLK; STPK13
UniProt ID: (Human) P53350, (Rat) Q62673, (Mouse) Q07832
Entrez Gene ID: (Human) 5347, (Rat) 25515, (Mouse) 18817
mitotic sister chromatid segregation
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
mitotic cell cycle
mitotic cytokinesis
microtubule bundle formation
double-strand break repair
protein phosphorylation
mitotic spindle organization
mitotic spindle assembly checkpoint
mitotic G2 DNA damage checkpoint
centrosome cycle
female meiotic division
regulation of mitotic cell cycle
female meiosis chromosome segregation
peptidyl-serine phosphorylation
regulation of mitotic metaphase/anaphase transition
astral microtubule organization
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
polar body extrusion after meiotic divisions
negative regulation of apoptotic process
homologous chromosome segregation
establishment of protein localization
positive regulation of mitotic metaphase/anaphase transition
synaptonemal complex disassembly
protein localization to chromatin
double-strand break repair via alternative nonhomologous end joining
regulation of mitotic spindle assembly
mitotic cleavage furrow formation
regulation of protein localization to cell cortex
positive regulation of mitotic nuclear envelope disassembly
negative regulation of double-strand break repair via homologous recombination
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
establishment of mitotic spindle orientation
double-strand break repair via homologous recombination
protein ubiquitination
protein destabilization
positive regulation of proteolysis
nuclear envelope disassembly
centrosome separation
protein localization to centrosome
protein localization to nuclear envelope
protein localization to site of double-strand break
nuclear division
sister chromatid cohesion
mitotic chromosome condensation
mitotic nuclear envelope disassembly
metaphase/anaphase transition of mitotic cell cycle
regulation of cell cycle process
Golgi inheritance
regulation of cell cycle
positive regulation of protein localization to nucleus
regulation of mitotic cell cycle phase transition
regulation of anaphase-promoting complex-dependent catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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