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Invitrogen

FGFR1 Monoclonal Antibody (M2F12)

View all (47) FGFR1 antibodies

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Additional Information:

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Product Details

37-9200

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (IHC)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

M2F12

Immunogen

Recombinant human FGF-R1-alpha (fibroblast growth factor receptor 1, alpha isoform) ectodomain

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533348

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.10.1; basic fibroblast growth factor receptor 1; CD331 antigen; FGF Receptor; FGF receptor-1; FGF receptor-1 precursor; FGFR; fgfr 1; FGFR1/PLAG1 fusion; fibroblast growth factor receptor (FGFr) transmembrane form; fibroblast growth factor receptor FGFR-1 secreted form; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; proto-oncogene c-Fgr; soluble form; FGF-R1; unnamed protein product

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Gene Aliases: bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; MFR; N-SAM; OGD

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UniProt ID: (Human) P11362, (Rat) Q04589

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Entrez Gene ID: (Human) 2260, (Rat) 79114

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding fibroblast growth factor binding identical protein binding protein homodimerization activity receptor-receptor interaction receptor binding SH2 domain binding macromolecular complex binding cell adhesion molecule binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis ureteric bud development in utero embryonic development organ induction epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation chondrocyte differentiation response to ischemia brain development salivary gland morphogenesis female pregnancy sensory perception of sound positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway gene expression regulation of gene expression negative regulation of gene expression positive regulation of fibroblast migration regulation of phosphate transport positive regulation of neuron projection development peptidyl-tyrosine phosphorylation stem cell population maintenance orbitofrontal cortex development postnatal olfactory bulb interneuron migration ventricular zone neuroblast division forebrain generation of neurons central nervous system neuron development tangential migration from the subventricular zone to the olfactory bulb lung development embryonic limb morphogenesis midbrain development neuron projection development response to nutrient levels fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development regulation of cell proliferation inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration ear development cellular response to fibroblast growth factor stimulus positive regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation blood vessel morphogenesis generation of neurons mesenchymal cell differentiation regulation of phosphorus metabolic process positive regulation of protein kinase B signaling calcium ion homeostasis positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vitamin D3 metabolic process cellular response to lipopolysaccharide diphosphate metabolic process cellular response to growth factor stimulus cellular response to histamine cementum mineralization regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production regulation of postsynaptic density assembly positive regulation of mitotic cell cycle DNA replication response to sodium phosphate positive regulation of vascular endothelial cell proliferation cellular response to nerve growth factor stimulus positive regulation of hepatic stellate cell activation positive regulation of parathyroid hormone secretion positive regulation of endothelial cell chemotaxis regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade skeletal system development neuron migration protein phosphorylation positive regulation of phospholipase activity cell migration chordate embryonic development regulation of cell differentiation phosphatidylinositol-mediated signaling skeletal system morphogenesis
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